Cyclic malonamides as inhibitors of A.beta. protein production
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United States of America Patent
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Jun 24, 2008
Grant Date -
Jan 24, 2008
app pub date -
Aug 20, 2007
filing date -
Apr 3, 2000
priority date (Note) -
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Abstract
This invention relates to novel cyclic malonamides having the formula (I): ##STR00001## to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease and Down's Syndrome.
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