Apparatus and method for delivery of mitomycin through an eluting biocompatible implantable medical device
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United States of America Patent
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Jul 8, 2008
Grant Date -
May 20, 2004
app pub date -
Sep 26, 2003
filing date -
Sep 26, 2002
priority date (Note) -
Expired
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Abstract
The present invention is an apparatus and a method for delivery of mitomycin through an eluting biocompatible implantable medical device. A biocompatible drug release matrix comprises a biocompatible drug release matrix and a drug incorporated into the biocompatible drug release matrix. The drug has antibiotic and anti-proliferative properties and is an analogue related to the quinone-containing alkylating agents of a mitomycin family. The drug is initially released from the biocompatible drug release matrix at a faster rate followed by a release at a slower rate. The drug release rate maintains tissue level concentrations of the drug for at least two weeks after implantation of the medical device. The present invention provides a coating for a vascular prosthesis that elutes the drug at a controlled rate to inhibit proliferation of smooth muscle cells causing restenosis.
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