Beta-lactamase substrates having phenolic ethers
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United States of America Patent
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Jul 8, 2008
Grant Date -
Jan 2, 2003
app pub date -
Jan 11, 2002
filing date -
Jan 12, 2001
priority date (Note) -
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Abstract
Provided are fluorescent substrates for .beta.-lactamases having the general formula I: ##STR00001## in which R is a benzyl, 2-thienylmethyl, or cyanomethyl group; R' is selected from the group consisting of H, physiologically acceptable salts or metal, ester groups, ammonium cations, --CHR.sub.2OCO(CH.sub.2).sub.nCH.sub.3, --CHR.sub.2OCOC(CH.sub.3).sub.3, acylthiomethyl, acyloxy-alpha-benzyl, deltabutyrolactonyl, methoxycarbonyloxymethyl, phenyl, methylsulphinylmethyl, .beta.-morpholinoethyl, dialkylaminoethyl, and dialkylaminocarbonyloxymethyl, in which R.sub.2 is selected from the group consisting of H and lower alkyl; A is selected from the group consisting of S, O, SO, SO.sub.2 and CH.sub.2; and Z is a donor fluorescent moiety. Also provided are methods of use of the compound of general formula I.
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