Chromatographic column and methods for controlling sorbent density
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United States of America Patent
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Jul 15, 2008
Grant Date -
Oct 13, 2005
app pub date -
Mar 4, 2005
filing date -
Sep 10, 2002
priority date (Note) -
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Abstract
Disclosed herein are apparatus and methods for mitigating column bed compression over time. This invention provides for an improved column design and method of controlling bed density in a chromatographic column using a protruding portion of a filter assembly. The invention results in a higher sorbent bed density than can normally be achieved using a fixed length column of conventional design. The invention may be implemented as a unique filter assembly or as a column tailored for the application and a matching filter assembly.
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