Heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors

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United States of America Patent

PATENT NO 7399767
APP PUB NO 20060205741A1
SERIAL NO

11334603

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Abstract

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The present invention is directed to novel heterocyclic benzo[c]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.

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Patent Owner(s)

Patent OwnerAddress
JANSSEN PHARMACEUTICA N VBEERSE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Li, Xiaojie Green Brook, NJ 66 161
Sui, Zhihua Exton, PA 129 723
Zhang, Xuqing Exton, PA 54 291

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