US Patent No: 7,404,927
Number of patents in Portfolio can not be more than 2000
Automated molecular pathology apparatus having fixed slide platforms
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Jul 29, 2008
Issued date -
Dec 2, 2005
filing date -
11/293,489
serial no -
In Force
status
Importance
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Abstract
Apparatus and methods for automatically staining or treating multiple tissue samples mounted on slides are provided, in which the slides and reagent bottles are held in fixed position, and the reagent and wash solutions brought to the slides.
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First Claim
Related Publications
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International Classification(s)
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- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 4,731,335 Method for treating thin samples on a surface employing capillary flow | 77 | 1985 | |
| 4,801,431 Slide pair holder and assembly | 38 | 1987 | |
| 5,023,187 Method and device for accelerated treatment of thin sample on surface | 68 | 1988 | |
| 4,975,250 Aligned slideholder and assembly | 13 | 1989 | |
| 5,232,664 Liquid dispenser | 86 | 1991 | |
| 5,595,707 Automated biological reaction apparatus | 151 | 1994 | |
| 5,650,327 Method for mixing reagent and sample mounted on a slide | 92 | 1995 | |
| 5,654,199 Method for rinsing a tissue sample mounted on a slide | 79 | 1995 | |
| 5,654,200 Automated slide processing apparatus with fluid injector | 101 | 1995 | |
| 6,093,574 Method and apparatus for rinsing a microscope slide | 75 | 1997 | |
| 6,594,537 Automated tissue assay using standardized chemicals and packages | 46 | 1998 | |
| 6,296,809 Automated molecular pathology apparatus having independent slide heaters | 110 | 1999 | |
| 6,352,861 Automated biological reaction apparatus | 92 | 1999 | |
| 6,192,945 Fluid dispenser | 31 | 2000 | |
| 6,582,962 Automated molecular pathology apparatus having independent slide heaters | 59 | 2000 | |
| 6,537,818 System and method of aspirating and dispensing reagent | 20 | 2001 | |
| 2007/0086,917 AUTOMATED MOLECULAR PATHOLOGY APPARATUS HAVING FIXED SLIDE PLATFORMS | 2 | 2006 | |
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| 4,847,208 Apparatus for immunohistochemical staining and method of rinsing a plurality of slides | 79 | 1987 | |
| 5,073,504 Apparatus and method for immunohistochemical staining | 82 | 1988 | |
| 5,316,452 Dispensing assembly with interchangeable cartridge pumps | 109 | 1992 | |
| 5,645,114 Dispensing assembly with interchangeable cartridge pumps | 93 | 1994 | |
| 5,947,167 Dispensing assembly with interchangeable cartridge pumps | 73 | 1997 | |
| 6,092,695 Interchangeable liquid dispensing cartridge pump | 68 | 1998 | |
| 6,096,271 Random access slide stainer with liquid waste segregation | 82 | 1998 | |
| 6,183,693 Random access slide stainer with independent slide heating regulation | 85 | 1998 | |
| 6,180,061 Moving platform slide stainer with heating elements | 69 | 1998 | |
| 6,541,261 Method using a slide stainer with independent slide heating regulation | 49 | 2000 | |
| 6,783,733 Random access slide stainer with independent slide heating regulation | 41 | 2001 | |
| 2004/0191,128 Slide stainer with heating | 18 | 2004 | |
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| 4,647,431 Device for maintaining a constant temperature for chemical analysis | 22 | 1985 | |
| 4,855,109 Chemical analysis apparatus | 74 | 1987 | |
| 5,154,889 Chemical analysis apparatus | 96 | 1987 | |
| 5,496,518 Incubator | 29 | 1994 | |
| 5,639,665 Method of spotting sample liquid on dry chemical analysis film | 16 | 1995 | |
| 6,531,094 Biochemical analysis apparatus | 6 | 1996 | |
| 5,879,944 Liquid spotting method and liquid spotting device | 19 | 1998 | |
| 6,241,947 Chemical analysis system and blood filtering unit | 13 | 1999 | |
| 2002/0037,239 Quantitative suction tip and quantitative suction apparatus | 10 | 2001 | |
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| 5,246,665 Heat and air flow control for assay carrier | 78 | 1991 | |
| 5,282,149 Adaptive scheduling system and method for a biological analyzer with reproducible operation time periods | 37 | 1991 | |
| 5,576,215 Adaptive scheduling system and method for operating a biological sample analyzer with variable interval periods | 50 | 1991 | |
| 5,376,313 Injection molding a plastic assay cuvette having low birefringence | 32 | 1992 | |
| 5,311,426 Apparatus and method for providing assay calibration data | 65 | 1992 | |
| 5,358,691 Automated continuous and random access analytical system | 120 | 1993 | |
| 5,646,049 Scheduling operation of an automated analytical system | 70 | 1994 | |
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| 4,406,547 Apparatus for effecting automatic analysis | 67 | 1980 | |
| 4,346,056 Automatic analyzing apparatus | 95 | 1980 | |
| 4,455,280 Apparatus for preserving liquid in automatic analyzer | 63 | 1982 | |
| 4,781,891 Automatic analyzing apparatus | 108 | 1983 | |
| 4,629,862 Sample heater for use in microscopes | 44 | 1984 | |
| 4,837,159 Method and apparatus for effecting immunological analysis | 72 | 1985 | |
| 4,971,913 Method for controlling reagent delivery system in automatic chemical analyzer | 48 | 1987 | |
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| 4,858,155 Reaction temperature control system | 50 | 1985 | |
| 4,933,146 Temperature control apparatus for automated clinical analyzer | 60 | 1986 | |
| 4,965,049 Modular analyzer system | 139 | 1989 | |
| 5,428,470 Modular system and method for an automatic analyzer | 56 | 1992 | |
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| 4,296,069 Apparatus for processing an analysis slide | 53 | 1980 | |
| 4,298,571 Incubator including cover means for an analysis slide | 110 | 1980 | |
| 4,539,855 Apparatus for transferring liquid out of a capped container, and analyzer utilizing same | 47 | 1984 | |
| 4,795,710 Mounting of analyzer sample tray | 40 | 1988 | |
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| 4,852,001 Job scheduling method and system | 100 | 1987 | |
| 5,051,238 Automatic analyzing system | 136 | 1988 | |
| 5,695,718 Automatic analyzer | 16 | 1995 | |
| 6,193,933 Automatic analysis apparatus | 26 | 1998 | |
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| 5,439,649 Automated staining apparatus | 166 | 1993 | |
| 5,948,359 Automated staining apparatus | 93 | 1997 | |
| 6,495,106 Automated staining apparatus | 78 | 2000 | |
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| 4,777,020 Sheetlike object such as microscope slide | 33 | 1987 | |
| 4,798,706 Device for holding horizontal array of liquid aliquots | 51 | 1987 | |
| 5,002,736 Microscope slide and slide assembly | 24 | 1987 | |
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| 4,708,886 Analysis system | 62 | 1985 | |
| 4,764,342 Reagent handling | 120 | 1985 | |
| 4,961,906 Liquid handling | 102 | 1988 | |
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| 4,727,494 Computerized robot control system with scheduling feature | 20 | 1986 | |
| 4,835,711 Quickly reconfigurable robotic system | 47 | 1988 | |
| 6,068,393 Robotic system for processing chemical products | 20 | 1997 | |
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| 4,843,566 Robot motion control system | 22 | 1988 | |
| 2003/0032,191 Sample processing apparatus and methods | 14 | 2001 | |
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| 5,475,610 Thermal cycler for automatic performance of the polymerase chain reaction with close temperature control | 144 | 1992 | |
| 5,656,493 System for automated performance of the polymerase chain reaction | 150 | 1994 | |
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| 4,528,159 Automated analysis instrument system | 129 | 1982 | |
| 4,815,978 Clinical analysis methods and systems | 44 | 1986 | |
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| 4,844,868 Automatic chemical analysis reagent distribution and analysis apparatus | 94 | 1986 | |
| 5,084,242 Distribution nozzle apparatus for automatic chemical analyzer | 84 | 1990 | |
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| 5,229,074 Automatic multiple-sample multiple-reagent chemical analyzer | 66 | 1991 | |
| 5,597,733 Automatic multiple-sample multiple-reagent dispensing method in chemical analyzer | 23 | 1995 | |
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| 5,352,612 Method and apparatus for the stepwise movement of items | 28 | 1993 | |
| 5,985,672 Method and apparatus for pre-treating samples in an automatic chemical analyzer | 60 | 1998 | |
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| 5,075,079 Slide analysis system | 112 | 1990 | |
| 5,213,764 Metering device for slide analysis system | 19 | 1991 | |
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| 5,105,066 Device comprising a heating sample carrier | 22 | 1989 | |
| 5,909,674 Method for optimizing the layout and charge maps of a flowline of pick and place machines | 13 | 1996 | |
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| 4,670,974 Windshield insertion system for a vehicle on a moving conveyor apparatus | 29 | 1985 | |
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| 5,273,905 Processing of slide mounted material | 85 | 1991 | |
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| 5,975,740 Apparatus, method and medium for enhancing the throughput of a wafer processing facility using a multi-slot cool down chamber and a priority transfer scheme | 47 | 1996 | |
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| 5,424,036 Automatic analyzer | 60 | 1993 | |
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| 4,678,752 Automatic random access analyzer | 192 | 1985 | |
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| 5,207,987 Temperature controlled chamber for diagnostic analyzer | 82 | 1990 | |
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| 4,635,791 Container package for staining biological specimens | 26 | 1985 | |
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| 5,355,439 Method and apparatus for automated tissue assay | 81 | 1991 | |
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| 4,695,430 Analytical apparatus | 117 | 1985 | |
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| 4,964,544 Push up dispenser with capsule valve | 56 | 1988 | |
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| RE30730 Apparatus for use in investigating specimens | 30 | 1979 | |
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| 5,601,141 High throughput thermal cycler | 122 | 1992 | |
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| 4,979,093 XYZ positioner | 66 | 1989 | |
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| 5,316,726 Automated immunoassay analyzer with pictorial display of assay information | 113 | 1992 | |
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| 4,286,637 Apparatus for dispensing liquids into tubes | 26 | 1980 | |
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| 4,895,706 Multi-well filter strip and composite assemblies | 95 | 1988 | |
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| 4,430,299 Apparatus for monitoring chemical reactions | 74 | 1981 | |
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| 5,439,645 Apparatus for automatically, selectively handling multiple, randomly associated hematological samples | 39 | 1993 | |
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| 4,865,986 Temperature control apparatus | 136 | 1988 | |
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| 6,673,620 Fluid exchange in a chamber on a microscope slide | 41 | 2000 | |
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| 4,935,875 Chemical analyzer | 89 | 1989 | |
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| 4,484,293 Dimensional measurement system served by a plurality of operating arms and controlled by a computer system | 27 | 1981 | |
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| 5,035,866 Luminescence reaction test apparatus | 61 | 1988 | |
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| 5,589,649 Dissolution testing apparatus | 32 | 1995 | |
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| 4,245,967 Pump for a hand actuated device for producing an atomized spray | 26 | 1978 | |
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| 4,979,128 Method of deciding robot layout | 15 | 1989 | |
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| 4,896,269 Job shop scheduling and production method and apparatus | 82 | 1988 | |
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| 5,040,123 Expert system scheduler | 54 | 1989 | |
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| 4,681,741 Reagent dispenser for an analyzing system | 64 | 1986 | |
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| 5,314,825 Chemical analyzer | 116 | 1992 | |
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| 5,431,309 Liquid soap dispenser for simplified replacement of soap reservoir | 73 | 1994 | |
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| 4,384,193 Incubating device for specimen mounted on glass slides in immunoassays | 54 | 1981 | |
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| 4,774,055 Automatic analysis apparatus | 152 | 1986 | |
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| 5,523,056 Twin rotor incubator assembly | 22 | 1994 | |
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| 5,304,347 Liquid transfer device for an analysis unit | 84 | 1993 | |
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| 5,839,091 Method and apparatus for automatic tissue staining | 68 | 1996 | |
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| 6,827,900 Automatic stainer having a heating station | 17 | 2001 | |
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| 5,122,959 Transportation dispatch and delivery tracking system | 195 | 1988 | |
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| 5,093,557 Substrate heater and heating element | 14 | 1989 | |
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| 4,902,481 Multi-well filtration test apparatus | 105 | 1987 | |
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| 5,116,496 Membrane-containing wells for microtitration and microfiltration | 50 | 1991 | |
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| 4,919,887 Automatic analyzer | 111 | 1988 | |
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| 5,355,695 Refrigeration device using hydrofluorocarbon refrigerant | 26 | 1992 | |
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| 5,280,156 Wafer heating apparatus and with ceramic substrate and dielectric layer having electrostatic chucking means | 202 | 1991 | |
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| 5,168,453 Work positioning method and apparatus | 34 | 1990 | |
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| 5,629,201 Apparatus for applying a liquid sample onto a culture medium | 12 | 1995 | |
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| 5,122,342 Bio-fluid assay apparatus | 95 | 1989 | |
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| 4,358,470 Process and apparatus for the treatment of samples with a succession of liquids | 39 | 1980 | |
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| 5,575,973 High strength high toughness spring steel, and manufacturing process therefor | 3 | 1995 | |
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| 4,805,469 Apparatus for automatically taking and analyzing samples of substances which are made available in random manner | 36 | 1987 | |
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| 5,231,029 Apparatus for the in situ hybridization of slide-mounted cell samples | 35 | 1992 | |
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| 5,737,498 Process automation method and apparatus | 23 | 1995 | |
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| 4,738,824 Apparatus for dyeing specimens automatically preparatory to microscopic examination | 57 | 1986 | |
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| 6,372,144 Method for concentrating or washing macromolecules in a solution and device for carrying out said method | 8 | 1995 | |
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| 4,927,765 Automatic reagent dispenser | 32 | 1988 | |
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| 4,659,971 Robot controlling system | 107 | 1985 | |
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| 4,985,206 Tissue processing apparatus | 73 | 1988 | |
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| 4,727,409 Programmable read-only memory formed with opposing PN diodes | 14 | 1985 | |
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| 6,296,764 Apparatus for mixing and separating particulate matter from a fluid | 18 | 1998 | |
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| 4,729,661 Asynchronous serial cuvette reader | 30 | 1985 | |
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| 5,148,370 Expert system and method for batch production scheduling and planning | 84 | 1991 | |
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| 5,479,581 Multiple library media exchange system and method | 44 | 1993 | |
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| 5,233,533 Scheduling method and apparatus | 132 | 1989 | |
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| 5,578,455 Method for determining endotoxin and apparatus therefor | 13 | 1994 | |
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| 4,807,152 Metrological apparatus | 51 | 1987 | |
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| 6,180,060 Analyzer transport device | 15 | 1995 | |
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| 5,402,350 Scheduling for multi-task manufacturing equipment | 41 | 1991 | |
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| 4,447,395 Sampling device | 37 | 1982 | |
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| 5,646,046 Method and instrument for automatically performing analysis relating to thrombosis and hemostasis | 68 | 1995 | |
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| 5,356,814 Disaggregation device for cytological specimens | 20 | 1993 | |
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| 4,577,514 Method and apparatus for sampling liquid phase components from a liquid-semisolid fluid | 28 | 1984 | |
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| 5,446,652 Constraint knowledge in simulation modeling | 39 | 1993 | |
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| 5,089,229 Chemical analyzer | 43 | 1989 | |
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| 5,425,918 Apparatus for automatic tissue staining for immunohistochemistry | 106 | 1993 | |
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| 5,180,606 Apparatus for applying a controlled amount of reagent to a microscope slide or the like | 35 | 1991 | |
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| 4,543,236 Incubating apparatus for selective and exact treatment of histological preparations | 29 | 1982 | |
| 4,648,023 Method for resource allocation for the manufacture of a product | 52 | 1986 | |
| 5,096,670 Automated patient sample analysis instrument | 83 | 1989 | |
| 5,525,302 Method and device for simultaneously transferring plural samples | 53 | 1991 | |
| 5,334,353 Micropipette device | 45 | 1993 | |
| 5,525,515 Process of handling liquids in an automated liquid handling apparatus | 59 | 1994 | |
| 5,512,248 Twin-probe blood sample diluting device | 30 | 1994 | |
| 5,819,842 Method and apparatus for temperature control of multiple samples | 138 | 1995 | |
| 5,736,105 Method and device for simultaneously transferring plural samples | 96 | 1996 | |
| 6,054,099 Urine specimen container | 43 | 1996 | |
| 5,861,094 Filter for biological particle separation | 18 | 1997 | |
| 5,875,286 Automated tissue assay using standarized chemicals and packages | 28 | 1997 | |
| 6,183,645 Methods and apparatus for liquid phase separation | 13 | 1998 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jan 29, 2016 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jan 29, 2020 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |