Transgenic mice expressing heterologous complement receptor type 1 (CR1) molecules on erythrocytes and uses therefor

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United States of America Patent

PATENT NO 7405342
APP PUB NO 20050028230A1
SERIAL NO

10843038

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Abstract

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The present invention is directed, at least in part, to mice which express exogenous complement receptor type 1 (CR1) on red blood cells. The invention also pertains to genetic constructs encoding heterologous CR1 for expression on red blood cells. Methods of using the transgenic animals of the invention to identify and/or evaluate compositions that can reduce the concentration of an agent, e.g., a biologic agent, in the serum, circulation and/or tissues of a subject are also provided.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF MASSACHUSETTSONE BEACON STREET 31ST FLOOR BOSTON MA 02108

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Finberg, Robert W Sudbury, MA 13 34

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