Combination of fenofibrate and coenzyme q10 for the treatment of endothelial dysfunction
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United States of America Patent
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Aug 12, 2008
Grant Date -
Feb 5, 2004
app pub date -
Oct 23, 2001
filing date -
Oct 26, 2000
priority date (Note) -
Expired
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Abstract
The present invention relates to a combination of a peroxisome proliferator activated receptor (PPAR) activator and a benzoquinone and their use in treating and/or preventing disorders characterized by endothelial dysfunction, such as cardiovascular disease, strokes and myocardial infarction. According to a preferred embodiment of the invention the benzoquinone or precursor thereof is a ubiquinone or precursor thereof, more preferably, coenzyme Q.sub.10 or a precursor thereof, and the PPAR activator is a fibrate or a thiazolidinedione, more preferably fenofibrate.
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