Active immunization using a siderophore receptor protein
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United States of America Patent
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Aug 19, 2008
Grant Date -
Feb 2, 2006
app pub date -
Jun 8, 2005
filing date -
Feb 9, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention provides a vaccine for immunizing poultry and other animals against infection by a gram-negative bacteria, and a method of immunizing an animal using the vaccine. The vaccine may contain purified siderophore receptor proteins derived from a single strain or species of gram-negative bacteria or other organism, which are cross-reactive with siderophores produced by two or more strains, species or genera of gram-negative bacteria. The invention further provides a process for isolating and purifying the siderophore receptor proteins, and for preparing a vaccine containing the proteins. Also provided is a method for diagnosing gram-negative sepsis.
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