US Patent No: 7,417,022

Number of patents in Portfolio can not be more than 2000

Compounds and compositions for delivering active agents

ALSO PUBLISHED AS: 20050186176

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Importance

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Abstract

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Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

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First Claim

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all claims..

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MHR INSTITUTIONAL PARTNERS IIA LPNEW YORK, NY2

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Leipold, Harry Elmsford, NY 23 517
Leone-Bay, Andrea Ridgefield, CT 125 2340
Milstein, Sam J Larchmont, NY 76 1816
Sarubbi, Donald J Bolton, MA 68 1366

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Emisphere Technologies, Inc. (73)
4,446,138 Method and composition for reducing weight 69 1982
4,925,673 Delivery systems for pharmacological agents encapsulated with proteinoids 293 1987
4,895,725 Microencapsulation of fish oil 107 1988
4,976,968 Anhydrous delivery systems for pharmacological agents 119 1989
4,983,402 Orally administerable ANF 80 1989
5,443,841 Proteinoid microspheres and methods for preparation and use thereof 67 1992
5,401,516 Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof 58 1993
5,451,410 Modified amino acids for encapsulating active agents 95 1993
5,578,323 Proteinoid carriers and methods for preparation and use thereof 85 1993
5,447,728 Desferrioxamine oral delivery system 80 1993
5,792,451 Oral drug delivery compositions and methods 96 1994
5,541,155 Acids and acid salts and their use in delivery systems 105 1994
5,629,020 Modified amino acids for drug delivery 106 1994
5,540,939 Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof 49 1994
5,643,957 Compounds and compositions for delivering active agents 101 1994
5,714,167 Active agent transport systems 67 1994
5,972,387 Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof 18 1994
5,709,861 Compositions for the delivery of antigens 67 1995
5,650,386 Compositions for oral delivery of active agents 102 1995
5,820,881 Microspheres of diamide-dicarboxylic acids 38 1995
5,601,846 Proteinoid microspheres and methods for preparation and use thereof 68 1995
5,958,457 Compositions for the delivery of antigens 44 1995
6,180,140 Modified amino acids for drug delivery 33 1995
5,667,806 Spray drying method and apparatus 70 1995
5,750,147 Method of solubilizing and encapsulating itraconazole 60 1995
5,824,345 Fragrances and flavorants 28 1995
6,051,258 Proteinoid emulsions and methods for preparation and use thereof 34 1995
5,811,127 Desferrioxamine oral delivery system 59 1996
5,840,340 Proteinoid carriers and methods for preparation and use thereof 28 1996
5,935,601 Modified amino acids for drug delivery 36 1996
6,099,856 Active agent transport systems 51 1996
5,866,536 Compounds and compositions for delivering active agents 69 1997
5,955,503 Compounds and compositions for delivering active agents 33 1997
5,965,121 Compounds and compositions for delivering active agents 44 1997
5,989,539 Compounds and compositions for delivering active agents 41 1997
6,001,347 Compounds and compositions for delivering active agents 51 1997
6,100,298 Compounds and compositions for delivering active agents 39 1997
5,773,647 Compounds and compositions for delivering active agents 68 1997
5,776,888 Compounds and compositions for delivering active agents 49 1997
5,804,688 Compounds and compositions for delivering active agents 36 1997
5,876,710 Compounds and compositions for delivering active agents 37 1997
5,879,681 Compounds and compositions for delivering active agents 39 1997
5,939,381 Compounds and compositions for delivering active agents 30 1997
5,990,166 Compounds and compositions for delivering active agents 42 1997
6,051,561 Compounds and compositions for delivering active agents 38 1997
6,060,513 Compounds and compositions for delivering active agents 39 1997
6,090,958 Compounds and compositions for delivering active agents 40 1997
6,358,504 Compounds and compositions for delivering active agents 21 1997
6,344,213 Compounds and compositions for delivering active agents 28 1997
6,071,510 Modified amino acids and compositions comprising the same for delivering active agents 47 1997
5,863,944 Compounds and compositions for delivering active agents 41 1997
5,962,710 Method of preparing salicyloylamino acids 29 1997
6,071,538 Oral delivery composition comprising supramolecular complex 40 1997
6,348,207 Orally deliverable supramolecular complex 21 1997
6,100,285 Method of solubilizing itraconazole 26 1997
6,084,112 Method for preparing .omega.-aminoalkanoic acid derivatives from cycloalkanones 20 1997
6,391,303 Methods and compositions for inducing oral tolerance in mammals 13 1999
6,428,780 Compounds and compositions for delivering active agents 19 1999
6,346,242 Compounds and compositions for delivering active agents 25 2000
6,384,278 Boron-mediated amidation of carboxylic acids 13 2001
6,642,411 Compounds and compositions for delivering active agents 16 2001
6,440,929 Pulmonary delivery of active agents 15 2001
6,461,643 Oral drug delivery compositions and methods 20 2001
6,610,329 Compositions for the delivery of antigens 17 2001
6,399,798 Method of preparing alkylated salicylamides 21 2001
6,646,162 Compounds and compositions for delivering active agents 17 2001
6,623,731 Compounds and compositions for delivering active agents 14 2001
6,525,020 Compounds and compositions for delivering active agents 14 2001
6,663,887 Compounds and compositions for delivering active agents 13 2002
6,699,467 Compounds and compositions for delivering active agents 16 2002
6,693,073 Pulmonary delivery of active agents 14 2002
6,693,208 Compounds and compositions for delivering active agents 16 2002
* 2005/0272,815 Compounds and compositions for delivering active agents 1 2005
 
MANNKIND CORPORATION (3)
5,352,461 Self assembling diketopiperazine drug delivery system 158 1992
5,693,338 Diketopiperazine-based delivery systems 87 1994
5,976,569 Diketopiperazine-based delivery systems 64 1997
 
Alkermes Controlled Therapeutics, Inc. (2)
5,019,400 Very low temperature casting of controlled release microspheres 294 1989
5,271,961 Method for producing protein microspheres 241 1992
 
CONNAUGHT LABORATORIES LIMITED (2)
4,492,684 Slow release injectable insulin composition 90 1983
4,673,566 Microencapsulation of living tissue and cells 156 1984
 
EASTMAN CHEMICAL COMPANY (2)
4,473,620 Encapsulated butylated hydroxyanisole 65 1982
4,590,265 Carboxylated cellulose ester and manufacture thereof 85 1985
 
FMC CORPORATION (2)
4,518,433 Enteric coating for pharmaceutical dosage forms 91 1982
4,462,839 Enteric coating for pharmaceutical dosage forms 110 1983
 
HOFFMANN-LA ROCHE INC. (2)
4,402,968 Antifungal benzofuranyl imidazole compounds 35 1981
5,278,148 Amino acid derivatives useful for treating high blood pressure 80 1990
 
REPLIGEN CORPORATION (2)
4,683,092 Capsule loading technique 48 1985
4,692,284 Method and apparatus for forming droplets and microcapsules 64 1986
 
TOYO JOZO KABUSHIKI KAISHA (2)
4,873,087 Suppository preparation having excellent absorption property 99 1982
4,900,730 Preparation which promotes the absorption of peptides 121 1987
 
ABBOTT LABORATORIES (1)
5,137,892 Quinoline, naphthyridine and pyridobenzoxazine derivatives 67 1990
 
ABRAXIS BIOSCIENCE, LLC (1)
5,439,686 Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor 179 1993
 
ALZA CORPORATION (1)
* 5,702,727 Compositions and methods for the oral delivery of active agents 25 1995
 
American Cyanamid Company (1)
4,837,381 Compositions for parenteral administration and their use 79 1987
 
ARTHUR D. LITTLE, INC. (1)
4,450,150 Biodegradable, implantable drug delivery depots, and method for preparing and using the same 229 1981
 
BAHN, PETER, FARMINGTON, CT, (5.0%) INTEREST (1)
4,963,364 Microencapsulated antitumor agent 77 1989
 
Bayer Aktiengesellschaft (1)
4,402,856 Microcapsules with a defined opening temperature, a process for their production and their use 111 1981
 
Biomaterials Universe, Inc. (1)
5,100,669 Polylactic acid type microspheres containing physiologically active substance and process for preparing the same 189 1989
 
BIOTECHNOLOGY MANAGEMENT ASSOCIATES, INCORPORATED (1)
5,126,147 Sustained release dosage form 112 1990
 
BOEHRINGER BIOCHEMIA ROBIN S.P.A. (1)
4,753,804 Granular dietetic product based on amino acids and process for their preparation 76 1985
 
CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.T.R.D. (1)
4,927,928 Aromatic benzamido compounds, their preparation and their use in human or veterinary medicine or in cosmetic preparations 66 1987
 
Ceskoslovenska akademie ved (1)
4,745,161 Soluble and biodegradable polyamino acid activated for bonding of biologically active compound 85 1986
 
CIBA-GEIGY CORPORATION (1)
5,328,992 Metal complexes of polyethylene glycol carbamate derivatives of desferrioxamine B 75 1992
 
Clean Air, Inc. (1)
5,039,481 Aliphatic polycarboxylic acids as air purification compositions 70 1990
 
CLEAR LAKE DEVELOPMENT GROUP, 201 N. MAIN, WICHITA, KN., 67202 A PARTNERSHIP (1)
4,457,907 Composition and method for protecting a therapeutic drug 99 1982
 
COLLAGEN MATRIX TECHNOLOGIES, INC. (1)
5,067,961 Non-biodegradable two phase corneal implant and method for preparing same 104 1990
 
CRYOGENIC TECHNOLOGY, INC. (1)
4,351,337 Biodegradable, implantable drug delivery device, and process for preparing and using the same 201 1980
 
DAINIPPON PHARMACEUTICAL CO., LTD. (1)
4,348,384 Pharmaceutical composition for oral administration containing coagulation factor VIII or IX 111 1981
 
Dr. Wolman GmbH (1)
5,186,947 Wood preservative based on polymeric nitrogen compounds and metal-fixing acids 82 1991
 
EURAND S.P.A. (1)
4,460,563 Process for preparing microcapsules in a liquid vehicle 90 1981
 
Farmaceutici Formenti S.p.A. (1)
4,766,012 Microencapsulation of a medicament 80 1986
 
Fisons Limited (1)
4,405,598 Composition for treating asthma 114 1981
 
G. D. Searle & Co. (1)
5,216,124 Substituted cyclic tetrapeptides 63 1991
 
Griffith Laboratories Worldwide, Inc. (1)
5,418,010 Microencapsulation process 90 1990
 
HODOGAYA CHEMICAL CO., LTD. (1)
4,878,942 Benzamide derivative, process for its production and plant growth regulant 52 1988
 
Hoechst Aktiengesellschaft (1)
5,041,291 Biodegradable poly(hydroxyalkyl)amino dicarboxylic acid) derivatives, a process for their preparation, and the use thereof for depot formulations with controlled deivery of active ingredient 52 1989
 
INNOVATA BIOMED LIMITED (1)
5,384,133 Pharmaceutical formulations comprising microcapsules 172 1993
 
INTERx Research Corporation (1)
4,462,991 Method of increasing oral absorption of polar bioactive agents 89 1982
 
ISP Chemicals Inc. (1)
5,244,653 Glycine anhydride dimethylol as a biocide and preservative 62 1991
 
Japan Atomic Energy Research Institute (1)
4,483,807 Process for producing a slow release composite 76 1982
 
KABUSHIKI KAISHA KUMIGAIGUMI (1)
4,289,759 Immunoregulatory diketopiperazine compounds 79 1980
 
Kyoto Yakuhin Kogyo Kabushiki Kaisha (1)
4,442,090 Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use 87 1981
 
La Jolla Cancer Research Foundation (1)
4,789,734 Vitronectin specific cell receptor derived from mammalian mesenchymal tissue 134 1985
 
LION CORPORATION (1)
4,908,233 Production of microcapsules by simple coacervation 83 1988
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
5,122,367 Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone 90 1989
 
MEDI-TECH, INCORPORATED (1)
4,388,304 Angiotensin-II analogues with antagonizing effects, containing an ester group in position 8, and a process for the preparation thereof 62 1981
 
MITSUI TOATSU CHEMICALS, INC. (1)
4,835,312 Production process of N-substituted amide compounds 97 1986
 
MOLECULAR BIOQUEST, INC. (1)
5,389,377 Solid care therapeutic compositions and methods for making same 66 1992
 
MORELLE, JEAN V. (1)
5,066,487 Antisudoral composition comprising dibasic aluminium salts of acylated amino acids 89 1989
 
N.V. ORGANON (1)
5,389,379 Process for the preparation of biologically active material containing polymeric microcapsules 70 1993
 
NISSHIN SEIFUN GROUP INC. (1)
5,705,529 N-benzoyl amino acid derivatives pharmaceutical compositions containing them and process for preparing same 70 1995
 
Nitto Electric Industrial Co., Ltd. (1)
4,690,786 Process for producing a microcapsule containing a liquid active material 63 1986
 
NORTHWESTERN UNIVERSITY (1)
4,345,588 Method of delivering a therapeutic agent to a target capillary bed 164 1980
 
NURTURE BIOTECH INC. A DE CORP. (1)
5,055,300 Time release protein 101 1989
 
PFIZER INC. (1)
5,077,278 Non-natural demethylavermectins compositions and method of use 61 1987
 
PHARMETRIX, MENLO PARK (1)
4,919,939 Periodontal disease treatment system 176 1988
 
PTLNV, LLC, SERIES ONE (1)
5,069,936 Manufacturing protein microspheres 167 1989
 
QUEEN'S UNIVERSITY AT KINGSTON (1)
4,647,455 Process for extracting atrial natriuretic factor 64 1984
 
REAADS MEDICAL PRODUCTS, INC., A DE CORP. (1)
4,757,024 Immune complex detection method and article using immunologically non-specific immunoglobulins 64 1985
 
REVLON CONSUMER PRODUCTS CORPORATION (1)
5,271,934 Encapsulated antiperspirant salts and deodorant/antiperspirants 78 1992
 
Rhone-Poulenc Chimie (1)
5,536,813 Detersive polyanhydroaspartic acids and biodegradable hydrolysates thereof 52 1994
 
RIBOZYME PHARMACEUTICALS, INC. (1)
5,583,020 Permeability enhancers for negatively charged polynucleotides 70 1993
 
SANKYO COMPANY, LIMITED (1)
4,757,066 Composition containing a penem or carbapenem antibiotic and the use of the same 100 1986
 
SANOFI, A FRENCH CORP. (1)
5,204,099 Cosmetic composition containing amino acid copolymers which is useful as a moisturizer 101 1991
 
SCLAVO S.P.A. (1)
4,774,320 Synthetic peptide with human interleukin 1 activity 70 1986
 
SEPRACOR INC. (1)
5,474,997 Methods and compositions of (2R,4S) itraconazole for treating fungal yeast and dermatophyte infections 46 1994
 
Skua Investments Limited (1)
5,665,700 Pharmaceutical formulations 79 1994
 
Standard Oil Company (Indiana) (1)
4,393,192 Crystalline copolymers prepared from N,N'-terephthaloyldi-beta-alanine and a glycol 63 1982
 
STERLING WINTHROP, INC. (1)
5,100,918 Prevention or treatment of sunburn using the S(+) isomer of ibuprofen 72 1990
 
TAKEDA CHEMICAL INDUSTRIES, LTD. (1)
4,844,904 Liposome composition 83 1986
 
TEIJIN LIMITED (1)
4,613,500 Powdery pharmaceutical composition for nasal administration 191 1984
 
The Dow Chemical Company (1)
5,310,535 Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies 48 1992
 
The Nisshin Oil Mills, Ltd. (1)
4,757,007 Process for preparing hydrolyzed products of soy protein 76 1985
 
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION (1)
4,608,278 Small particule formation and encapsulation 93 1984
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4,692,433 Method and composition for regulating serum calcium levels of mammals 88 1985
 
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (1)
4,897,444 Immobilized fluorogenic substrates for enzymes; and processes for their preparation 87 1985
 
The Scripps Research Institute (1)
4,886,663 Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof 66 1983
 
UNIVERSITE PARIS-SUD (1)
4,666,641 Preparation of biodegradable microcapsules based on serum albumin 65 1985
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
4,671,954 Microspheres for incorporation of therapeutic substances and methods of preparation thereof 140 1986
 
VIRGINIA COMMONWEALTH UNIVERSITY (1)
6,627,228 Polymeric delivery agents and delivery agents compounds 24 2001
 
WILLI MOLLER AG (1)
5,023,374 Dicarboxylic acid diamides, process for their preparation, ion selective members and test means containing them as well as lithium complexes of the dicarboxylic acid amides 45 1990
 
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai (1)
5,206,384 Actinonin derivatives and pharmaceutically acceptable salts thereof 59 1991
 
Other [Check patent profile for assignment information] (4)
4,703,042 Orally active heparin salts containing multivalent cationic units 71 1985
4,708,952 Method of treatment of the infectious and viral diseases by one time interference 58 1986
4,996,292 Self-sealing artificial skin comprising copoly-alpha-amino acid 83 1989
5,250,236 Method for producing solid lipid microspheres having a narrow size distribution 86 1991
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Emisphere Technologies, Inc. (1)
* 8,686,154 Compounds and compositions for delivering active agents 0 2009
* Cited By Examiner

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