Compounds and compositions for delivering active agents

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7417022
APP PUB NO 20050186176A1
SERIAL NO

11104173

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

Modified amino acid compounds useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
MHR INSTITUTIONAL PARTNERS IIA LPNEW YORK, NY2

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Leipold, Harry Elmsford, NY 19 627
Leone-Bay, Andrea Ridgefield, CT 120 2925
Milstein, Sam J Larchmont, NY 59 2380
Sarubbi, Donald J Bolton, MA 52 1687

Cited Art Landscape

Patent Info (Count) # Cites Year
 
EMISPHERE TECHNOLOGIES, INC. (73)
4446138 Method and composition for reducing weight 72 1982
4925673 Delivery systems for pharmacological agents encapsulated with proteinoids 340 1987
4895725 Microencapsulation of fish oil 114 1988
4976968 Anhydrous delivery systems for pharmacological agents 128 1989
4983402 Orally administerable ANF 92 1989
5443841 Proteinoid microspheres and methods for preparation and use thereof 82 1992
5401516 Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof 73 1993
5451410 Modified amino acids for encapsulating active agents 111 1993
5578323 Proteinoid carriers and methods for preparation and use thereof 107 1993
5447728 Desferrioxamine oral delivery system 94 1993
5792451 Oral drug delivery compositions and methods 115 1994
5541155 Acids and acid salts and their use in delivery systems 116 1994
5629020 Modified amino acids for drug delivery 128 1994
5540939 Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof 51 1994
5643957 Compounds and compositions for delivering active agents 124 1994
5714167 Active agent transport systems 83 1994
5972387 Modified hydrolyzed vegetable protein microspheres and methods for preparation and use thereof 20 1994
5709861 Compositions for the delivery of antigens 74 1995
5650386 Compositions for oral delivery of active agents 120 1995
5820881 Microspheres of diamide-dicarboxylic acids 40 1995
5601846 Proteinoid microspheres and methods for preparation and use thereof 82 1995
5958457 Compositions for the delivery of antigens 44 1995
6180140 Modified amino acids for drug delivery 35 1995
5667806 Spray drying method and apparatus 74 1995
5750147 Method of solubilizing and encapsulating itraconazole 62 1995
5824345 Fragrances and flavorants 44 1995
6051258 Proteinoid emulsions and methods for preparation and use thereof 36 1995
5811127 Desferrioxamine oral delivery system 73 1996
5840340 Proteinoid carriers and methods for preparation and use thereof 42 1996
5935601 Modified amino acids for drug delivery 38 1996
6099856 Active agent transport systems 62 1996
5866536 Compounds and compositions for delivering active agents 83 1997
5955503 Compounds and compositions for delivering active agents 40 1997
5965121 Compounds and compositions for delivering active agents 54 1997
5989539 Compounds and compositions for delivering active agents 49 1997
6001347 Compounds and compositions for delivering active agents 59 1997
6100298 Compounds and compositions for delivering active agents 48 1997
5773647 Compounds and compositions for delivering active agents 82 1997
5776888 Compounds and compositions for delivering active agents 58 1997
5804688 Compounds and compositions for delivering active agents 44 1997
5876710 Compounds and compositions for delivering active agents 45 1997
5879681 Compounds and compositions for delivering active agents 47 1997
5939381 Compounds and compositions for delivering active agents 37 1997
5990166 Compounds and compositions for delivering active agents 50 1997
6051561 Compounds and compositions for delivering active agents 45 1997
6060513 Compounds and compositions for delivering active agents 48 1997
6090958 Compounds and compositions for delivering active agents 49 1997
6358504 Compounds and compositions for delivering active agents 28 1997
6344213 Compounds and compositions for delivering active agents 35 1997
6071510 Modified amino acids and compositions comprising the same for delivering active agents 57 1997
5863944 Compounds and compositions for delivering active agents 48 1997
5962710 Method of preparing salicyloylamino acids 31 1997
6071538 Oral delivery composition comprising supramolecular complex 43 1997
6348207 Orally deliverable supramolecular complex 27 1997
6100285 Method of solubilizing itraconazole 28 1997
6084112 Method for preparing .omega.-aminoalkanoic acid derivatives from cycloalkanones 22 1997
6391303 Methods and compositions for inducing oral tolerance in mammals 15 1999
6428780 Compounds and compositions for delivering active agents 22 1999
6346242 Compounds and compositions for delivering active agents 27 2000
6384278 Boron-mediated amidation of carboxylic acids 15 2001
6642411 Compounds and compositions for delivering active agents 18 2001
6440929 Pulmonary delivery of active agents 17 2001
6461643 Oral drug delivery compositions and methods 22 2001
6610329 Compositions for the delivery of antigens 19 2001
6399798 Method of preparing alkylated salicylamides 23 2001
6646162 Compounds and compositions for delivering active agents 19 2001
6623731 Compounds and compositions for delivering active agents 18 2001
6525020 Compounds and compositions for delivering active agents 16 2001
6663887 Compounds and compositions for delivering active agents 15 2002
6699467 Compounds and compositions for delivering active agents 19 2002
6693073 Pulmonary delivery of active agents 15 2002
6693208 Compounds and compositions for delivering active agents 19 2002
* 2005/0272,815 Compounds and compositions for delivering active agents 2 2005
 
Other [Check patent profile for assignment information] (4)
4703042 Orally active heparin salts containing multivalent cationic units 77 1985
4708952 Method of treatment of the infectious and viral diseases by one time interference 58 1986
4996292 Self-sealing artificial skin comprising copoly-alpha-amino acid 83 1989
5250236 Method for producing solid lipid microspheres having a narrow size distribution 88 1991
 
SCLAVO S.P.A. (1)
4774320 Synthetic peptide with human interleukin 1 activity 70 1986
 
La Jolla Cancer Research Foundation (1)
4789734 Vitronectin specific cell receptor derived from mammalian mesenchymal tissue 147 1985
 
Dr. Wolman GmbH (1)
5186947 Wood preservative based on polymeric nitrogen compounds and metal-fixing acids 85 1991
 
NURTURE BIOTECH INC. A DE CORP. (1)
5055300 Time release protein 104 1989
 
The Nisshin Oil Mills, Ltd. (1)
4757007 Process for preparing hydrolyzed products of soy protein 77 1985
 
DAINIPPON PHARMACEUTICAL CO., LTD. (1)
4348384 Pharmaceutical composition for oral administration containing coagulation factor VIII or IX 114 1981
 
STERLING WINTHROP, INC. (1)
5100918 Prevention or treatment of sunburn using the S(+) isomer of ibuprofen 74 1990
 
VIRGINIA COMMONWEALTH UNIVERSITY (1)
6627228 Polymeric delivery agents and delivery agents compounds 36 2001
 
Biomaterials Universe Incorporated (1)
5100669 Polylactic acid type microspheres containing physiologically active substance and process for preparing the same 198 1989
 
PFIZER INC. (1)
5077278 Non-natural demethylavermectins compositions and method of use 61 1987
 
G. D. Searle & Co. (1)
5216124 Substituted cyclic tetrapeptides 66 1991
 
CIBA-GEIGY CORPORATION (1)
5328992 Metal complexes of polyethylene glycol carbamate derivatives of desferrioxamine B 76 1992
 
HOECHST AKTIENGESELLSCHAFT (1)
5041291 Biodegradable poly(hydroxyalkyl)amino dicarboxylic acid) derivatives, a process for their preparation, and the use thereof for depot formulations with controlled deivery of active ingredient 52 1989
 
Reaads Medical Products, Inc. (1)
4757024 Immune complex detection method and article using immunologically non-specific immunoglobulins 64 1985
 
HODOGAYA CHEMICAL CO., LTD. (1)
4878942 Benzamide derivative, process for its production and plant growth regulant 52 1988
 
HOFFMANN-LA ROCHE INC. (2)
4402968 Antifungal benzofuranyl imidazole compounds 35 1981
5278148 Amino acid derivatives useful for treating high blood pressure 83 1990
 
REPLIGEN CORPORATION (2)
4683092 Capsule loading technique 51 1985
4692284 Method and apparatus for forming droplets and microcapsules 64 1986
 
CLEAR LAKE DEVELOPMENT GROUP, 201 N. MAIN, WICHITA, KN., 67202 A PARTNERSHIP (1)
4457907 Composition and method for protecting a therapeutic drug 107 1982
 
PTLNV, LLC, SERIES ONE (1)
5069936 Manufacturing protein microspheres 183 1989
 
UNIVERSITY OF FLORIDA (1)
4671954 Microspheres for incorporation of therapeutic substances and methods of preparation thereof 147 1986
 
The Standard Oil Company (1)
4393192 Crystalline copolymers prepared from N,N'-terephthaloyldi-beta-alanine and a glycol 63 1982
 
Clean Air, Inc. (1)
5039481 Aliphatic polycarboxylic acids as air purification compositions 70 1990
 
REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE (1)
4692433 Method and composition for regulating serum calcium levels of mammals 88 1985
 
ARTHUR D. LITTLE, INC. (1)
4450150 Biodegradable, implantable drug delivery depots, and method for preparing and using the same 286 1981
 
RIBOZYME PHARMACEUTICALS, INC. (1)
5583020 Permeability enhancers for negatively charged polynucleotides 85 1993
 
ABBOTT LABORATORIES (1)
5137892 Quinoline, naphthyridine and pyridobenzoxazine derivatives 67 1990
 
Ceskoslovenska akademie ved (1)
4745161 Soluble and biodegradable polyamino acid activated for bonding of biologically active compound 86 1986
 
ISP Chemicals Inc. (1)
5244653 Glycine anhydride dimethylol as a biocide and preservative 74 1991
 
Skua Investments Limited (1)
5665700 Pharmaceutical formulations 82 1994
 
N.V. ORGANON (1)
5389379 Process for the preparation of biologically active material containing polymeric microcapsules 71 1993
 
COLLAGEN MATRIX TECHNOLOGIES, INC. (1)
5067961 Non-biodegradable two phase corneal implant and method for preparing same 113 1990
 
Bayer Aktiengesellschaft (1)
4402856 Microcapsules with a defined opening temperature, a process for their production and their use 111 1981
 
MANNKIND CORPORATION (3)
5352461 Self assembling diketopiperazine drug delivery system 194 1992
5693338 Diketopiperazine-based delivery systems 114 1994
5976569 Diketopiperazine-based delivery systems 108 1997
 
FISONS LIMITED (1)
4405598 Composition for treating asthma 114 1981
 
NISSHIN SEIFUN GROUP INC. (1)
5705529 N-benzoyl amino acid derivatives pharmaceutical compositions containing them and process for preparing same 70 1995
 
SANKYO COMPANY, LIMITED (1)
4757066 Composition containing a penem or carbapenem antibiotic and the use of the same 112 1986
 
THE OHIO STATE UNIVERSITY (1)
4608278 Small particule formation and encapsulation 97 1984
 
KABUSHIKI KAISHA KUMIGAIGUMI (1)
4289759 Immunoregulatory diketopiperazine compounds 99 1980
 
TOYO JOZO KABUSHIKI KAISHA (1)
4900730 Preparation which promotes the absorption of peptides 135 1987
 
ABRAXIS BIOSCIENCE, LLC (1)
5439686 Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor 215 1993
 
UNIVERSITE PARIS-SUD (1)
4666641 Preparation of biodegradable microcapsules based on serum albumin 65 1985
 
AMERICAN CYANAMID COMPANY (1)
4837381 Compositions for parenteral administration and their use 84 1987
 
TAKEDA CHEMICAL INDUSTRIES, LTD. (1)
4844904 Liposome composition 87 1986
 
BIOTECHNOLOGY MANAGEMENT ASSOCIATES, INCORPORATED (1)
5126147 Sustained release dosage form 119 1990
 
INTERx Research Corporation (1)
4462991 Method of increasing oral absorption of polar bioactive agents 89 1982
 
QUEEN'S UNIVERSITY AT KINGSTON (1)
4647455 Process for extracting atrial natriuretic factor 64 1984
 
Farmaceutici Formenti S.p.A. (1)
4766012 Microencapsulation of a medicament 80 1986
 
TOYO JOZO COMPANY, LTD. (1)
4873087 Suppository preparation having excellent absorption property 113 1982
 
ALZA CORPORATION (1)
* 5702727 Compositions and methods for the oral delivery of active agents 42 1995
 
Rhone-Poulenc Chimie (1)
5536813 Detersive polyanhydroaspartic acids and biodegradable hydrolysates thereof 52 1994
 
Nitto Electric Industrial Co., Ltd. (1)
4690786 Process for producing a microcapsule containing a liquid active material 63 1986
 
TEIJIN LIMITED (1)
4613500 Powdery pharmaceutical composition for nasal administration 211 1984
 
NORTHWESTERN UNIVERSITY (1)
4345588 Method of delivering a therapeutic agent to a target capillary bed 199 1980
 
PHARMETRIX, MENLO PARK (1)
4919939 Periodontal disease treatment system 195 1988
 
The Scripps Research Institute (1)
4886663 Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof 67 1983
 
THE DOW CHEMICAL COMPANY (1)
5310535 Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies 48 1992
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
5122367 Polyanhydride bioerodible controlled release implants for administration of stabilized growth hormone 90 1989
 
BOEHRINGER BIOCHEMIA ROBIN S.P.A. (1)
4753804 Granular dietetic product based on amino acids and process for their preparation 80 1985
 
CRYOGENIC TECHNOLOGY, INC. (1)
4351337 Biodegradable, implantable drug delivery device, and process for preparing and using the same 215 1980
 
FMC CORPORATION (2)
4518433 Enteric coating for pharmaceutical dosage forms 105 1982
4462839 Enteric coating for pharmaceutical dosage forms 117 1983
 
MITSUI TOATSU CHEMICALS, INC. (1)
4835312 Production process of N-substituted amide compounds 111 1986
 
Griffith Laboratories Worldwide, Inc. (1)
5418010 Microencapsulation process 107 1990
 
Kyoto Yakuhin Kogyo Kabushiki Kaisha (1)
4442090 Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use 87 1981
 
SANOFI, A FRENCH CORP. (1)
5204099 Cosmetic composition containing amino acid copolymers which is useful as a moisturizer 102 1991
 
MORELLE, JEAN V. (1)
5066487 Antisudoral composition comprising dibasic aluminium salts of acylated amino acids 89 1989
 
EURAND S.P.A. (1)
4460563 Process for preparing microcapsules in a liquid vehicle 106 1981
 
Japan Atomic Energy Research Institute (1)
4483807 Process for producing a slow release composite 76 1982
 
MOLECULAR BIOQUEST, INC. (1)
5389377 Solid care therapeutic compositions and methods for making same 66 1992
 
UNIVERSITY OF MIAMI (1)
4963364 Microencapsulated antitumor agent 77 1989
 
LION CORPORATION (1)
4908233 Production of microcapsules by simple coacervation 86 1988
 
Alkermes Controlled Therapeutics, Inc. (2)
5019400 Very low temperature casting of controlled release microspheres 337 1989
5271961 Method for producing protein microspheres 266 1992
 
CONNAUGHT LABORATORIES LIMITED (2)
4492684 Slow release injectable insulin composition 94 1983
4673566 Microencapsulation of living tissue and cells 165 1984
 
MEDI-TECH, INCORPORATED, A CORP OF MA (1)
4388304 Angiotensin-II analogues with antagonizing effects, containing an ester group in position 8, and a process for the preparation thereof 62 1981
 
The Research Foundation of State University of New York (1)
4897444 Immobilized fluorogenic substrates for enzymes; and processes for their preparation 90 1985
 
SEPRACOR INC. (1)
5474997 Methods and compositions of (2R,4S) itraconazole for treating fungal yeast and dermatophyte infections 47 1994
 
REVLON CONSUMER PRODUCTS CORPORATION (1)
5271934 Encapsulated antiperspirant salts and deodorant/antiperspirants 78 1992
 
INNOVATA BIOMED LIMITED (1)
5384133 Pharmaceutical formulations comprising microcapsules 181 1993
 
ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (1)
5206384 Actinonin derivatives and pharmaceutically acceptable salts thereof 59 1991
 
CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.T.R.D. (1)
4927928 Aromatic benzamido compounds, their preparation and their use in human or veterinary medicine or in cosmetic preparations 78 1987
 
EASTMAN CHEMICAL COMPANY (2)
4473620 Encapsulated butylated hydroxyanisole 65 1982
4590265 Carboxylated cellulose ester and manufacture thereof 91 1985
 
WILLI MOLLER AG (1)
5023374 Dicarboxylic acid diamides, process for their preparation, ion selective members and test means containing them as well as lithium complexes of the dicarboxylic acid amides 45 1990
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
EMISPHERE TECHNOLOGIES, INC. (1)
* 8686154 Compounds and compositions for delivering active agents 0 2009
* Cited By Examiner

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
11.5 Year Payment $7400.00 $3700.00 $1850.00 Feb 26, 2020
Fee Large entity fee small entity fee micro entity fee
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00