Mass spectrometric methods for detecting mutations in a target nucleic acid
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United States of America Patent
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Sep 2, 2008
Grant Date -
Oct 5, 2006
app pub date -
May 11, 2006
filing date -
Mar 17, 1995
priority date (Note) -
Expired
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Abstract
Provided herein in certain embodiments are processes that generally include the following steps: amplifying a target nucleic acid molecule; ionizing and volatilizing the amplification product and analyzing the ionized and volatilized product by mass spectrometry. In some embodiments the amplification product is a natural nucleic acid and detection of the target nucleotide sequence by mass spectrometry indicates the presence of the target nucleotide sequence in the biological sample.
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