Device and method for monitoring leukocyte migration
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United States of America Patent
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-
Sep 2, 2008
Grant Date -
Jul 22, 2004
app pub date -
Oct 21, 2003
filing date -
Nov 8, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A device for monitoring leukocyte migration is provided. The invention also provides a method of using the device to monitor leukocyte migration in the presence of physiological shear flow and therefore simulate physiological conditions of a blood vessel in vivo. The invention further provides a method of using the device to high-throughput screen a plurality of test agents. The present invention further provides a flexible assay system and numerous assays that can be used to test biological interactions and systems. Laminar flow gradients are employed that mimic gradient situations present in vivo.
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