Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof
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United States of America Patent
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Sep 9, 2008
Grant Date -
Jun 15, 2006
app pub date -
Jan 30, 2004
filing date -
Feb 14, 2003
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The present invention provides compounds represented by general formula (I): ##STR00001## or pharmaceutical acceptable salts thereof, wherein R.sup.1 and R.sup.2 are each hydrogen or lower alkyl; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are each hydrogen, halogen, lower alkyl or lower alkoxy; R.sup.7 and R.sup.8 are each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; R.sup.9 is --C(O)--R.sup.10, -A.sup.1-C(O)--R.sup.10, --O-A.sup.2-C(O)--R.sup.10 or a tetrazol-5-yl group, which exhibit potent and selective .beta.3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.
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