Vaccines against West Nile Virus
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United States of America Patent
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Sep 16, 2008
Grant Date -
Aug 25, 2005
app pub date -
Apr 20, 2005
filing date -
Nov 26, 1999
priority date (Note) -
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Abstract
The present invention relates to novel vaccines containing (whole-inactivated) West Nile Viruses and/or West Nile viral proteins derived therefrom, produced on human cells, wherein the human cells comprise a sequence encoding at least one early region-1 (E1) gene product of an adenovirus. The cells are preferably cultured in suspension to very high densities and under serum-free conditions. Herein, it is disclosed that use of such cells results in high titers of West Nile Virus produced.
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