pH controlled fermentation process for pseudomonic acid production
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United States of America Patent
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Oct 21, 2008
Grant Date -
Feb 6, 2003
app pub date -
Jun 21, 2002
filing date -
Jun 21, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20-30.degree. C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.
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