Method for detecting the expression of an envelope protein of a human endogenous retrovirus and uses of a gene coding for said protein
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United States of America Patent
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Oct 28, 2008
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app pub date -
Sep 1, 2000
filing date -
Sep 1, 1999
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Abstract
A method for detecting the expression of a polypeptide in cells and for detecting the interaction between a polypeptide and cells, ex vivo or in vitro, wherein the polypeptide is selected from the group consisting of: a peptide comprising the cyt domain of the envelope protein of the human endogenous retrovirus, HERV-W; a peptide comprising amino acids 448-538 of SEQ ID NO: 1; and a peptide comprising a sequence having, for any series of 20 amino acids, at least 80% identity with amino acids 448-538 of SEQ ID NO: 1. Detection is established by the fusogenic power of the polypeptide, which is demonstrated by syncytia formation.
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