Detection of negatively charged polymers using water-soluble, cationic, polythiophene derivatives
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United States of America Patent
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Nov 4, 2008
Grant Date -
Jul 20, 2006
app pub date -
Mar 7, 2006
filing date -
Apr 5, 2001
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Expired
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Abstract
Novel methods allowing for the simple optical detection and electrochemical detection of doubled-straded oligonucleotides are disclosed. The methods are rapid, selective and versatile. Advantageously, they do not require any chemical reaction on the probes or on the analytes since they are based on different electrostatic interactions between cationic poly(3-alkoxy-4-methylthiophene) derivatives and single-stranded or doubled-stranded (hybridized) oligonucleotides.
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