US Patent No: 7,448,375

Number of patents in Portfolio can not be more than 2000

Method of treating diabetes mellitus in a patient

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ALSO PUBLISHED AS: 20050274377
ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA118

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Farr, Stephen J Orinda, CA 40 579
Gonda, Igor San Francisco, CA 80 964
Rubsamen, Reid M Oakland, CA 95 4686

Cited Art

Patent Info (Count) # Cites Year
 
ARADIGM CORPORATION (34)
5,364,838 Method of administration of insulin 164 1993
5,394,866 Automatic aerosol medication delivery system and methods 114 1993
5,450,336 Method for correcting the drift offset of a transducer 61 1993
5,509,404 Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values 147 1994
5,419,315 Intrapulmonary delivery of hormones 59 1994
5,522,385 Dynamic particle size control for aerosolized drug delivery 122 1994
5,558,085 Intrapulmonary delivery of peptide drugs 31 1994
5,672,581 Method of administration of insulin 53 1994
5,915,378 Creating an aerosolized formulation of insulin 135 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 173 1995
6,012,450 Intrapulmonary delivery of hematopoietic drug 115 1996
5,743,250 Insulin delivery enhanced by coached breathing 116 1996
5,888,477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 29 1997
5,884,620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 46 1997
6,131,567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 43 1998
6,192,882 Formulation and devices for monitoring the efficacy of the delivery of aerosols 44 1998
6,085,753 Insulin delivery enhanced by coached breathing 37 1998
6,123,068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 45 1998
5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range 16 1998
5,970,973 Method of delivering insulin lispro 50 1998
6,098,615 Method of reproducibly effecting a patient's glucose level 37 1998
6,024,090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 16 1998
5,941,240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 44 1998
6,167,880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 60 1999
6,408,854 Insulin delivery enhanced by coached breathing 23 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 38 2000
6,263,872 Temperature controlling device for aerosol drug delivery 61 2000
6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 20 2001
6,427,681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
6,688,304 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 11 2001
6,431,167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 6 2001
6,647,987 Insulin delivery enhanced by coached breathing 3 2002
7,021,309 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 2 2003
7,028,686 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 9 2003
 
NOVARTIS PHARMA AG (6)
5,098,893 Storage of materials 99 1990
5,458,135 Method and device for delivering aerosolized medicaments 192 1992
6,051,256 Dispersible macromolecule compositions and methods for their preparation and use 76 1996
5,997,848 Methods and compositions for pulmonary delivery of insulin 109 1997
6,019,968 Dispersible antibody compositions and methods for their preparation and use 84 1997
6,737,045 Methods and compositions for the pulmonary delivery insulin 22 2002
 
THE JOHNS HOPKINS UNIVERSITY (4)
4,790,305 Medication delivery system 130 1986
4,926,852 Medication delivery system phase one 141 1988
5,027,806 Medication delivery system phase two 80 1990
5,320,094 Method of administering insulin 96 1992
 
ASTRAZENECA AB (3)
4,907,583 Device in powder inhalators 131 1988
5,506,203 Systemic administration of a therapeutic preparation 123 1994
5,518,998 Therapeutic preparation for inhalation 118 1994
 
AUTOIMMUNE, INC. (3)
5,763,396 Method of treating or preventing type 1 diabetes by oral administration of insulin 36 1995
5,843,886 Method of treating or preventing Type 1 diabetes by oral administration of insulin 10 1995
5,643,868 Method of treating or preventing type 1 diabetes by oral administration of insulin 9 1995
 
GLAXO GROUP LIMITED (3)
4,627,432 Devices for administering medicaments to patients 247 1983
4,811,731 Devices for administering medicaments to patients 185 1986
4,778,054 Pack for administering medicaments to patients 101 1986
 
IMMUNEX CORPORATION (3)
4,968,607 Interleukin-1 receptors 79 1988
5,081,228 Interleukin-1 receptors 64 1988
5,180,812 Soluble human interleukin-1 receptors, compositions and method of use 70 1989
 
MINNESOTA MINING AND MANUFACTURING COMPANY (3)
5,167,506 Inhalation device training system 100 1991
5,666,948 Attachment for aerosol device for large animals and method of use 9 1995
6,012,454 Dry powder inhalation device 40 1997
 
RIKER LABORATORIES, INC. (3)
4,446,862 Breath actuated devices for administering powdered medicaments 89 1981
4,624,251 Apparatus for administering a nebulized substance 90 1984
4,635,627 Apparatus and method 29 1984
 
TRUDELL MEDICAL LIMITED (3)
4,534,343 Metered dose inhaler 122 1984
4,796,614 Collapsible inhalation valve 51 1987
5,954,049 Equine mask with MDI adapter 61 1992
 
3M INNOVATIVE PROPERTIES COMPANY (2)
5,192,548 Device 60 1990
5,619,984 Dry powder inhalation device having a powder-loaded elongate carrier 72 1995
 
BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH, INC. (2)
5,200,399 Method of protecting biological materials from destructive reactions in the dry state 58 1991
5,290,765 Method of protecting biological materials from destructive reactions in the dry state 85 1992
 
BRITISH TECHNOLOGY GROUP LIMITED (2)
5,254,330 Aerosol carriers 86 1991
5,376,386 Aerosol carriers 97 1992
 
CHR. HANSEN, INC. (2)
4,956,295 Stabilization of dried bacteria extended in particulate carriers 30 1987
4,927,763 Stabilization of dried bacteria extended in particulate carriers 24 1988
 
GENENTECH, INC. (2)
6,099,517 Intrapulmonary delivery of polypeptide growth factors and cytokines 20 1993
6,402,733 Intrapulmonary delivery of polypeptide growth factors and cytokines 8 2000
 
GLAXO INC. (2)
5,161,524 Dosage inhalator with air flow velocity regulating means 159 1991
5,376,359 Method of stabilizing aerosol formulations 103 1992
 
KING PHARMACEUTICALS, INC. (2)
4,590,206 Inhalation pharmaceuticals 107 1984
5,260,306 Inhalation pharmaceuticals 94 1991
 
QUADRANT BIORESOURCES LIMITED (2)
4,891,319 Protection of proteins and the like 153 1987
5,026,566 Dried food containing trehalose and method for preparing same 68 1989
 
TAKEDA CHEMICAL INDUSTRIES, LTD. (2)
4,211,769 Preparations for vaginal administration 49 1978
4,659,696 Pharmaceutical composition and its nasal or vaginal use 129 1983
 
THE GENERAL HOSPITAL CORPORATION (2)
4,698,328 Method of increasing bone mass 78 1986
4,833,125 Method of increasing bone mass 85 1987
 
UNIVERSITY OF SOUTHWESTERN LOUISIANA (2)
4,806,343 Cryogenic protectant for proteins 50 1986
4,897,353 Cryogenic protection of phosphofructokinase using amino acids and zinc ions 24 1986
 
ABBOTT LABORATORIES (1)
5,302,581 Pulmonary surfactant protein fragments 45 1992
 
AKTIEBOLAGET DRACO (1)
5,331,953 Device in connection with an inhaler 120 1993
 
AMERICAN NATIONAL RED CROSS (1)
4,559,298 Cryopreservation of biological materials in a non-frozen or vitreous state 96 1982
 
AMGEN INC. (1)
5,354,934 Pulmonary administration of erythropoietin 87 1993
 
ANDI-VENTIS LIMITED (1)
5,033,463 Multi-dose inhaler for medicaments in powder form 139 1990
 
ARMOUR PHARMACEUTICAL COMPANY (1)
4,876,241 Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants 41 1988
 
ARMSTRONG PHARMACEUTICALS, INC. (1)
5,284,133 Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means 198 1992
 
BAYLOR COLLEGE OF MEDICINE (1)
4,649,911 Small particle aerosol generator for treatment of respiratory disease including the lungs 93 1986
 
BIOGEN IDEC MA INC. (1)
5,356,635 Carbohydrate glass matrix for the sustained release of a therapeutic agent 40 1993
 
BOEHRINGER INGELHEIM INTERNATIONAL GMBH (1)
5,497,944 Atomising devices and methods 136 1992
 
BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (1)
5,320,714 Powder inhalator 76 1992
 
CALIFORNIA BIOTECHNOLOGY INC. (1)
5,011,678 Composition and method for administration of pharmaceutically active substances 134 1989
 
CALIFORNIA INSTITUTE OF TECHNOLOGY (1)
4,931,361 Cryoprotective reagents in freeze-drying membranes 33 1988
 
CAREFUSION 2200, INC (1)
5,099,833 High efficiency nebulizer having a flexible reservoir 55 1991
 
CHIRON BEHRING GMBH & CO. (1)
4,206,200 Stabilizer for polysaccharides 23 1978
 
CIS-US, INC., A CORP OF MA (1)
4,823,784 Aerosol inhalation apparatus 90 1987
 
E. R. SQUIBB & SONS, INC. (1)
4,830,858 Spray-drying method for preparing liposomes and products produced thereby 131 1985
 
ECONOMICS LABORATORY, INC. (1)
4,617,272 Enzyme drying process 33 1984
 
FISONS LIMITED (1)
4,249,526 Inhalation device 47 1979
 
FUJI OIL COMPANY, LIMITED (1)
4,855,157 Process for producing fat powder 23 1988
 
GENERAL FOODS CORPORATION (1)
4,820,534 Fixation of volatiles in extruded glass substrates 50 1988
 
HASTINGS, DONALD H. (1)
5,017,372 Method of producing antibody-fortified dry whey 54 1988
 
HOFFMANN-LA ROCHE INC. (1)
4,503,035 Protein purification process and product 60 1983
 
INNOVATA BIOMED LIMITED (1)
5,384,133 Pharmaceutical formulations comprising microcapsules 161 1993
 
INVENSENSE, INC. (1)
2005/0170,656 Vertical integration of a MEMS structure with electronics in a hermetically sealed cavity 2004
 
KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (1)
4,824,938 Water-soluble dry solid containing proteinaceous bioactive substance 51 1987
 
KEY PHARMACEUTICALS, INC. (1)
4,484,577 Drug delivery method and inhalation device therefor 142 1982
 
KRAFT FOODS GLOBAL BRANDS LLC (1)
5,124,162 Spray-dried fixed flavorants in a carbohydrate substrate and process 57 1991
 
KRAFT FOODS HOLDINGS, INC. (1)
4,919,962 Coffee flakes and process 36 1988
 
LANPHER DIAGNOSTIC WORKSTATIONS, INC. (1)
5,363,842 Intelligent inhaler providing feedback to both patient and medical professional 273 1991
 
LEIRAS OY (1)
5,295,479 Device intended for measuring a dose of powdered medicament for inhalation 46 1993
 
LIPOSOME TECHNOLOGY, INC. (1)
4,895,719 Method and apparatus for administering dehydrated liposomes by inhalation 270 1987
 
MAQUET CRITICAL CARE AB (1)
4,819,629 Method and apparatus for delivering aerosol to the airways and/or lungs of a patient 245 1987
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
5,482,927 Controlled released microparticulate delivery system for proteins 54 1994
 
MCINTOSH; KENNETH B. (1)
4,942,544 Medication clock 86 1989
 
MIAT S.P.A. (1)
4,884,565 Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola 72 1988
 
MIRIS MEDICAL INCORPORATED, A CORP. OF CA (1)
5,404,871 Delivery of aerosol medications for inspiration 248 1991
 
MOULDING, THOMAS S., JR. (1)
4,604,847 Medicine package, method of opening the package, and machine for performing the method 110 1983
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
4,889,114 Powdered pharmaceutical inhaler 87 1987
 
NIPPON SHINYAKU CO., LTD. (1)
4,533,552 Stabilization of azulene derivatives 14 1983
 
NOVO NORDISK A/S (1)
4,946,828 Novel insulin peptides 62 1987
 
PAUL RITZAU PARI-WERK GMBH (1)
5,309,900 Atomizer particularly for use in devices for inhalation therapy 79 1991
 
PENNSYLVANIA RESEARCH CORPORATION, THE (1)
5,149,543 Ionically cross-linked polymeric microcapsules 153 1990
 
PH&T S.R.L. (1)
4,995,385 Inhaler with regular complete emptying of the capsule 83 1990
 
QUADRANT BIORESOURCES LIMITED, CAMBRIDGE RESEARCH LABORATORIES, 181A HUNTINGDON ROAD, CAMBRIDGE, CB3 ODJ, GREAT BRITAIN (1)
5,149,653 Preservation of viruses 71 1989
 
RESEARCH DEVELOPMENT FOUNDATION (1)
5,049,388 Small particle aerosol liposome and liposome-drug combinations for medical use 163 1989
 
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (1)
5,042,975 Iontotherapeutic device and process and iontotherapeutic unit dose 142 1987
 
SAINT-GOBAIN VITRAGE (1)
4,807,814 Pneumatic powder ejector 50 1986
 
SCIOS NOVA INC. (1)
5,006,343 Pulmonary administration of pharmaceutically active substances 118 1988
 
SFFB, SAN FRANCISCO FRENCH BREAD COMPANY, A CORP OF CALIFORNIA (1)
4,423,079 Growth promoting compositions for Lactobacillus sanfrancisco and method of preparation 14 1982
 
SIEMENS AKTIENGESELLSCHAFT (1)
4,877,989 Ultrasonic pocket atomizer 196 1989
 
SIERRA BIOTECHNOLOGY COMPANY, L.C. (1)
4,984,158 Metered dose inhaler biofeedback training and evaluation system 260 1988
 
SMITHKLINE BECKMAN CORPORATION (1)
4,686,231 Inhibition of 5-lipoxygenase products 101 1986
 
SOMOVA S.P.A. (1)
5,048,514 Inhaler for medicaments contained in capsules 70 1990
 
SONORAN DESERT CHEMICALS LIMITED LIABILITY COMPANY (1)
5,093,316 Treatment of inflammation 44 1990
 
SORIN BIOMEDICA S.P.A. (1)
5,139,016 Process and device for aerosol generation for pulmonary ventilation scintigraphy 63 1989
 
SRI INTERNATIONAL (1)
5,354,562 Process for preparing micronized polypeptide drugs 106 1993
 
TEIJIN LIMITED (1)
4,294,829 Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof 67 1980
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4,857,319 Method for preserving liposomes 86 1987
 
THERMO JARRELL ASH CORPORATION (1)
4,361,401 Automatic sample deposition in flameless analysis 58 1980
 
TOSHIBA HEATING APPLIANCES CO., LTD. (1)
4,719,762 Stored ice detecting device in ice making apparatus 20 1986
 
UNIVERSITY OF AUCKLAND (1)
4,677,975 Method of dispensing and/or a dispenser 295 1985
 
UNIVERSITY OF SOUTHERN MISSISSIPPI (1)
5,206,200 Tin catalysts for hydrolysis of latent amine curing agents 22 1991
 
VALOIS (1)
5,447,151 Powder inhaler with suction actuated locking means 69 1993
 
WALES COLLEGE OF CARDIFF (1)
5,230,884 Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations 106 1992
 
WEST PHARMACEUTICAL SERVICES DRUG DELIVERY & CLINICAL RESEARCH CENTRE LIMITED (1)
5,204,108 Transmucosal formulations of low molecular weight peptide drugs 120 1990
 
ZYMOGENETICS, INC. (1)
4,599,311 Glycolytic promotersfor regulated protein expression: protease inhibitor 59 1982
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (12)
4,253,468 Nebulizer attachment 87 1978
4,294,624 Drying co-mingled carbohydrate solution and recycled product by dielectric heating 31 1980
4,338,931 Device for the quick inhalation of drugs in powder form by humans suffering from asthma 81 1980
4,452,239 Medical nebulizing apparatus 81 1981
4,739,754 Suction resistant inhalator 73 1986
5,035,237 Devices for administering medicaments to patients 119 1988
5,113,855 Powder inhaler 109 1990
5,186,164 Mist inhaler 112 1991
5,253,468 Crop chopping machine 11 1991
5,201,308 Powder inhaler 85 1992
5,349,947 Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow 129 1993
5,755,221 Aerosol inhaler with piston dump 24 1994

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
MANNKIND CORPORATION (1)
8,424,518 Dry powder inhaler and system for drug delivery 0 2009

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 May 11, 2016
11.5 Year Payment $7400.00 $3700.00 $1850.00 May 11, 2020
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00