US Patent No: 7,448,375

Number of patents in Portfolio can not be more than 2000

Method of treating diabetes mellitus in a patient

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Abstract

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Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA60

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Farr, Stephen J Orinda, CA 45 883
Gonda, Igor San Francisco, CA 88 1548
Rubsamen, Reid M Oakland, CA 98 6461

Cited Art Landscape

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5,997,848 Methods and compositions for pulmonary delivery of insulin 171 1997
6,019,968 Dispersible antibody compositions and methods for their preparation and use 188 1997
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Genentech, Inc. (2)
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Andi-Ventis Limited (1)
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Armour Pharmaceutical Company (1)
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NOVO NORDISK A/S (1)
4,946,828 Novel insulin peptides 82 1987
 
UNIVERSITY OF AUCKLAND (1)
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KING PHARMACEUTICALS, INC. (2)
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5,260,306 Inhalation pharmaceuticals 132 1991
 
ASTRAZENECA AB (3)
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5,506,203 Systemic administration of a therapeutic preparation 174 1994
5,518,998 Therapeutic preparation for inhalation 147 1994
 
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BAYLOR COLLEGE OF MEDICINE (1)
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Economics Laboratory, Inc. (1)
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GLAXO GROUP LIMITED (3)
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University of Southwestern Louisiana (2)
4,806,343 Cryogenic protectant for proteins 57 1986
4,897,353 Cryogenic protection of phosphofructokinase using amino acids and zinc ions 24 1986
 
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4,635,627 Apparatus and method 32 1984
 
ARADIGM CORPORATION (34)
5,364,838 Method of administration of insulin 216 1993
5,394,866 Automatic aerosol medication delivery system and methods 161 1993
5,450,336 Method for correcting the drift offset of a transducer 70 1993
5,509,404 Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values 205 1994
5,419,315 Intrapulmonary delivery of hormones 69 1994
5,522,385 Dynamic particle size control for aerosolized drug delivery 146 1994
5,558,085 Intrapulmonary delivery of peptide drugs 33 1994
5,672,581 Method of administration of insulin 80 1994
5,915,378 Creating an aerosolized formulation of insulin 147 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 257 1995
6,012,450 Intrapulmonary delivery of hematopoietic drug 150 1996
5,743,250 Insulin delivery enhanced by coached breathing 150 1996
5,888,477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 57 1997
5,884,620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 70 1997
6,131,567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 59 1998
6,192,882 Formulation and devices for monitoring the efficacy of the delivery of aerosols 48 1998
6,085,753 Insulin delivery enhanced by coached breathing 37 1998
6,123,068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 66 1998
5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range 17 1998
5,970,973 Method of delivering insulin lispro 61 1998
6,098,615 Method of reproducibly effecting a patient's glucose level 37 1998
6,024,090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 17 1998
5,941,240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 51 1998
6,167,880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 68 1999
6,408,854 Insulin delivery enhanced by coached breathing 33 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 40 2000
6,263,872 Temperature controlling device for aerosol drug delivery 73 2000
6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 27 2001
6,427,681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
6,688,304 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 12 2001
6,431,167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 9 2001
6,647,987 Insulin delivery enhanced by coached breathing 3 2002
7,021,309 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 3 2003
7,028,686 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 28 2003
 
The Johns Hopkins University (4)
4,790,305 Medication delivery system 181 1986
4,926,852 Medication delivery system phase one 172 1988
5,027,806 Medication delivery system phase two 115 1990
5,320,094 Method of administering insulin 128 1992
 
Trudell Medical Limited (3)
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4,796,614 Collapsible inhalation valve 64 1987
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MAQUET CRITICAL CARE AB (1)
4,819,629 Method and apparatus for delivering aerosol to the airways and/or lungs of a patient 315 1987
 
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2003/0126,250 Systems for communicating current and future activity information among mobile internet users and methods therefor 82 2002
 
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BTG INTERNATIONAL LIMITED (2)
5,254,330 Aerosol carriers 97 1991
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RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (1)
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* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
9,511,198 Dry powder inhaler and system for drug delivery 0 2013
 
MANNKIND CORPORATION (16)
8,636,001 Dry powder inhaler and system for drug delivery 14 2009
8,499,757 Dry powder inhaler and system for drug delivery 14 2009
8,424,518 Dry powder inhaler and system for drug delivery 16 2009
9,364,619 Interactive apparatus and method for real-time profiling of inhalation efforts 0 2009
8,485,180 Dry powder drug delivery system 16 2010
9,358,352 Dry powder drug delivery system and methods 0 2011
9,364,436 High capacity diketopiperazine microparticles and methods 0 2012
9,339,615 Dry powder inhaler and system for drug delivery 0 2013
8,912,193 Dry powder inhaler and system for drug delivery 1 2013
9,393,372 Dry powder drug delivery system 0 2013
9,241,903 Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent 0 2013
9,283,193 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 0 2014
9,346,766 Catalysis of diketopiperazine synthesis 0 2014
9,446,133 Dry powder inhaler and system for drug delivery 0 2014
9,220,687 Substituted diketopiperazine analogs for use as drug delivery agents 0 2014
9,446,001 Increasing drug affinity for crystalline microparticle surfaces 0 2015
 
Mankind Corporation (1)
9,192,675 Dry powder inhaler and system for drug delivery 0 2013
 
ARADIGM CORPORATION (1)
* 2008/0099,011 INHALED INSULIN DOSAGE CONTROL DELIVERY ENHANCED BY CONTROLLING TOTAL INHALED VOLUME 5 2007
 
TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (1)
9,233,159 Methods and compositions for treating pain 0 2012
* Cited By Examiner

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