US Patent No: 7,448,375

Number of patents in Portfolio can not be more than 2000

Method of treating diabetes mellitus in a patient

ALSO PUBLISHED AS: 20050274377
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Abstract

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Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA62

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Farr, Stephen J Orinda, CA 53 670
Gonda, Igor San Francisco, CA 97 1152
Rubsamen, Reid M Oakland, CA 108 5442

Cited Art Landscape

Patent Info (Count) # Cites Year
 
ARADIGM CORPORATION (34)
5,364,838 Method of administration of insulin 181 1993
5,394,866 Automatic aerosol medication delivery system and methods 132 1993
5,450,336 Method for correcting the drift offset of a transducer 67 1993
5,509,404 Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values 184 1994
5,419,315 Intrapulmonary delivery of hormones 64 1994
5,522,385 Dynamic particle size control for aerosolized drug delivery 136 1994
5,558,085 Intrapulmonary delivery of peptide drugs 31 1994
5,672,581 Method of administration of insulin 60 1994
5,915,378 Creating an aerosolized formulation of insulin 135 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 203 1995
6,012,450 Intrapulmonary delivery of hematopoietic drug 135 1996
5,743,250 Insulin delivery enhanced by coached breathing 127 1996
5,888,477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 37 1997
5,884,620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 49 1997
6,131,567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 43 1998
6,192,882 Formulation and devices for monitoring the efficacy of the delivery of aerosols 46 1998
6,085,753 Insulin delivery enhanced by coached breathing 37 1998
6,123,068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 52 1998
5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range 16 1998
5,970,973 Method of delivering insulin lispro 51 1998
6,098,615 Method of reproducibly effecting a patient's glucose level 37 1998
6,024,090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 16 1998
5,941,240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 44 1998
6,167,880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 62 1999
6,408,854 Insulin delivery enhanced by coached breathing 25 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 38 2000
6,263,872 Temperature controlling device for aerosol drug delivery 64 2000
6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 20 2001
6,427,681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
6,688,304 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 11 2001
6,431,167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 9 2001
6,647,987 Insulin delivery enhanced by coached breathing 3 2002
7,021,309 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 3 2003
7,028,686 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 13 2003
 
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5,997,848 Methods and compositions for pulmonary delivery of insulin 131 1997
6,019,968 Dispersible antibody compositions and methods for their preparation and use 120 1997
6,737,045 Methods and compositions for the pulmonary delivery insulin 26 2002
 
The Johns Hopkins University (4)
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5,843,886 Method of treating or preventing Type 1 diabetes by oral administration of insulin 10 1995
5,643,868 Method of treating or preventing type 1 diabetes by oral administration of insulin 9 1995
 
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Other [Check patent profile for assignment information] (11)
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* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
MANNKIND CORPORATION (4)
8,636,001 Dry powder inhaler and system for drug delivery 1 2009
8,499,757 Dry powder inhaler and system for drug delivery 1 2009
8,424,518 Dry powder inhaler and system for drug delivery 1 2009
8,485,180 Dry powder drug delivery system 1 2010
 
Other [Check patent profile for assignment information] (1)
8,912,193 Dry powder inhaler and system for drug delivery 0 2013
* Cited By Examiner

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