US Patent No: 7,448,375

Number of patents in Portfolio can not be more than 2000

Method of treating diabetes mellitus in a patient

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Abstract

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Dosages of inhaled insulin are controlled within a narrow range by controlling the total volume of air inhaled by a patient. By repeatedly delivering aerosolized insulin with the same total inhaled volume of air, the amount of insulin delivered to the patient each time is consistent. A device for delivering insulin by inhalation is disclosed which device comprises a means for measuring inhaled volume and for halting inhalation at a pre-determined point. The device also comprises an adjustable means for applying various amounts of force to a container of formulation to expel different amounts of drug from the container based on the force applied.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ARADIGM CORPORATIONHAYWARD, CA57

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Farr, Stephen J Orinda, CA 41 782
Gonda, Igor San Francisco, CA 85 1414
Rubsamen, Reid M Oakland, CA 96 6132

Cited Art Landscape

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Other [Check patent profile for assignment information] (11)
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5,035,237 Devices for administering medicaments to patients 161 1988
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Somova S.p.A. (1)
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NOVARTIS PHARMA AG (6)
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5,458,135 Method and device for delivering aerosolized medicaments 258 1992
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5,997,848 Methods and compositions for pulmonary delivery of insulin 154 1997
6,019,968 Dispersible antibody compositions and methods for their preparation and use 160 1997
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Glaxo Inc. (2)
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Immunex Corporation (3)
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5,149,543 Ionically cross-linked polymeric microcapsules 173 1990
 
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PAUL RITZAU PARI-WERK GMBH (1)
5,309,900 Atomizer particularly for use in devices for inhalation therapy 96 1991
 
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Saint-Gobain Vitrage (1)
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4,946,828 Novel insulin peptides 75 1987
 
UNIVERSITY OF AUCKLAND (1)
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5,260,306 Inhalation pharmaceuticals 119 1991
 
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* 5,192,548 Device 66 1990
 
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ECONOMICS LABORATORY, INC., (1)
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GLAXO GROUP LIMITED (3)
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CAREFUSION 2200, INC. (1)
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University of Southwestern Louisiana (2)
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4,897,353 Cryogenic protection of phosphofructokinase using amino acids and zinc ions 24 1986
 
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Aradigm Corporation (34)
5,364,838 Method of administration of insulin 201 1993
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5,450,336 Method for correcting the drift offset of a transducer 68 1993
5,509,404 Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values 201 1994
5,419,315 Intrapulmonary delivery of hormones 68 1994
5,522,385 Dynamic particle size control for aerosolized drug delivery 143 1994
5,558,085 Intrapulmonary delivery of peptide drugs 32 1994
5,672,581 Method of administration of insulin 72 1994
5,915,378 Creating an aerosolized formulation of insulin 144 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 234 1995
6,012,450 Intrapulmonary delivery of hematopoietic drug 150 1996
5,743,250 Insulin delivery enhanced by coached breathing 140 1996
5,888,477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 48 1997
5,884,620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 60 1997
6,131,567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 52 1998
6,192,882 Formulation and devices for monitoring the efficacy of the delivery of aerosols 48 1998
6,085,753 Insulin delivery enhanced by coached breathing 37 1998
6,123,068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 61 1998
5,873,358 Method of maintaining a diabetic patient's blood glucose level in a desired range 17 1998
5,970,973 Method of delivering insulin lispro 57 1998
6,098,615 Method of reproducibly effecting a patient's glucose level 37 1998
6,024,090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 17 1998
5,941,240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 48 1998
6,167,880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 66 1999
6,408,854 Insulin delivery enhanced by coached breathing 30 2000
6,250,298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 39 2000
6,263,872 Temperature controlling device for aerosol drug delivery 70 2000
6,431,166 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 24 2001
6,427,681 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 5 2001
6,688,304 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 12 2001
6,431,167 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 9 2001
6,647,987 Insulin delivery enhanced by coached breathing 3 2002
7,021,309 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 3 2003
7,028,686 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 19 2003
 
THE JOHNS HOPKINS UNIVERSITY (4)
4,790,305 Medication delivery system 174 1986
4,926,852 Medication delivery system phase one 164 1988
5,027,806 Medication delivery system phase two 107 1990
5,320,094 Method of administering insulin 120 1992
 
Trudell Medical (3)
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BTG INTERNATIONAL LIMITED (2)
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RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (1)
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* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
MANNKIND CORPORATION (8)
8,636,001 Dry powder inhaler and system for drug delivery 6 2009
8,499,757 Dry powder inhaler and system for drug delivery 6 2009
8,424,518 Dry powder inhaler and system for drug delivery 8 2009
8,485,180 Dry powder drug delivery system 8 2010
8,912,193 Dry powder inhaler and system for drug delivery 0 2013
9,241,903 Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent 0 2013
9,283,193 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 0 2014
9,220,687 Substituted diketopiperazine analogs for use as drug delivery agents 0 2014
 
Mankind Corporation (1)
9,192,675 Dry powder inhaler and system for drug delivery 0 2013
 
TORREY PINES INSTITUTE FOR MOLECULAR STUDIES (1)
9,233,159 Methods and compositions for treating pain 0 2012
* Cited By Examiner

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