Method of determining cytokine dosage for improving myelosuppressive state
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United States of America Patent
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Dec 16, 2008
Grant Date -
Feb 15, 2007
app pub date -
Aug 7, 2006
filing date -
Jan 29, 1999
priority date (Note) -
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Abstract
The invention provides kits and methods for evaluating the myelosuppressive state of a patient. These methods and kits provide a useful adjunct for cytotoxic and myelosuppressive therapies. By establishing threshold levels of certain cytokines as a surrogate for myelosuppression, treatment protocols can be optimized to reduce myelotoxicity, while maximizing effective dose. Measured levels of one or more cytokines in a patient subjected to cytotoxic therapy, relative to a normal population, may be used to determine the dose of a hematopoietic cytokine to be administered to the patient.
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