De-immunized streptokinase
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United States of America Patent
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Dec 16, 2008
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N/A
app pub date -
Sep 6, 2006
filing date -
May 21, 1997
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Abstract
A target protein is rendered less immunogenic to a given species by (a) determining at least part of the amino acid sequence of the target protein; (b) identifying in the amino acid sequence one or more potential epitopes for T-cells ('T-cell epitopes') of the given species; and (c) modifying the amino acid sequence to eliminate at least one of the T-cell epitopes identified in step (b) to reduce the immunogenicity of the protein when exposed to the immune system of the given species.
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