US Patent No: 7,476,509
Number of patents in Portfolio can not be more than 2000
Compounds and methods for modulating functions of nonclassical cadherins
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Jan 13, 2009
Issued date -
Nov 14, 2003
filing date -
10/714,564
serial no -
Expired
status
Importance
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Abstract
Modulating agents and methods for enhancing or inhibiting nonclassical cadherin-mediated functions, such as atypical or desmosomal cadherin-mediated functions, are provided. The modulating agents comprise at least a tryptophan-containing cell adhesion recognition sequence of an atypical and/or desmosomal cadherin, a conservative analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, pharmaceutically active substance and/or support material.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
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| 6,472,367 Compounds and methods for modulating OB-cadherin mediated cell adhesion | 7 | 1998 | |
| 6,277,824 Compounds and methods for modulating adhesion molecule function | 9 | 1998 | |
| 6,358,920 Compounds and methods for modulating nonclassical cadherin-mediated functions | 14 | 1998 | |
| 6,110,747 Compounds and methods for modulating tissue permeability | 11 | 1998 | |
| 6,303,576 Compounds and methods for modulating .beta.-catenin mediated gene expression | 6 | 1999 | |
| 6,433,149 Compounds and methods for inhibiting cancer metastasis | 10 | 1999 | |
| 6,391,855 Compounds and methods for modulating junctional adhesion molecule-mediated functions | 17 | 1999 | |
| 6,472,368 Compounds and methods for modulating adhesion molecule function | 5 | 1999 | |
| 6,310,177 Compounds and methods for modulating tissue permeability | 5 | 2000 | |
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| 6,031,072 Compounds and methods for modulating cell adhesion | 29 | 1997 | |
| 6,169,071 Compounds and methods for modulating cell adhesion | 18 | 1997 | |
| 6,207,639 Compounds and methods for modulating neurite outgrowth | 7 | 1998 | |
| 6,346,512 Compounds and methods for modulating cell adhesion | 7 | 1999 | |
| 6,562,786 Compounds and methods for modulating apoptosis | 5 | 1999 | |
| 6,333,307 Compounds and method for modulating neurite outgrowth | 4 | 1999 | |
| 6,417,325 Compounds and methods for cancer therapy | 5 | 1999 | |
| 6,465,427 Compounds and methods for modulating cell adhesion | 5 | 1999 | |
| 6,326,352 Compounds and methods for modulating cell adhesion | 10 | 2000 | |
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| 5,643,781 DNA encoding protocadherin-42 | 14 | 1992 | |
| 5,597,725 Cadherin-specific antibodies and hybridoma cell lines | 22 | 1994 | |
| 5,639,634 Cadherin polynucleotides | 18 | 1994 | |
| 5,646,250 Cadherin polypeptides | 41 | 1994 | |
| 5,663,300 Protocadherin-42 | 8 | 1995 | |
| 5,708,143 Protocadherin materials and methods | 14 | 1995 | |
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| 6,203,788 Compounds and methods for regulating cell adhesion | 7 | 1997 | |
| 6,248,864 Compounds and methods and modulating tissue permeability | 6 | 1997 | |
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| 6,936,587 Anti-invasive and anti-angiogenic compositions | 1 | 2003 | |
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| 5,811,514 Integrin blocking molecule | 12 | 1995 | |
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| 6,600,013 Moraxella catarrhalis BASB034 polypeptides and uses thereof | 2 | 2001 | |
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| 5,869,683 Processes for producing 1-substituted-2-cyanoimidazole compounds | 1 | 1997 | |
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| 5,916,771 Production of a multimeric protein by cell fusion method | 95 | 1996 | |
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| 5,585,351 T-cadherin adhesion molecule | 27 | 1994 | |
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| 6,713,450 Synthetic immunogenic but non-amyloidogenic peptides homologous to amyloid .beta. for induction of an immune response to amyloid .beta. and amyloid deposits | 26 | 2001 | |
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| 5,610,281 Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes | 22 | 1994 | |
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| 6,060,595 Inhibition of viral replication | 3 | 1997 | |
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| 6,083,713 Cloning and expression of .beta.APP-C100 receptor (C100-R) | 3 | 1995 | |
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| 5,455,228 Peptidase resistant thrombin receptor peptide ligand | 10 | 1993 | |
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| 5,895,748 Panel of antibodies for detecting cadherins and catenins in tissues and method of using the panel of antibodies | 8 | 1996 | |
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Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jul 13, 2016 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jul 13, 2020 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |