N-heterocyclic inhibitors of TNF-α expression
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United States of America Patent
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Jan 20, 2009
Grant Date -
Oct 27, 2005
app pub date -
Jun 2, 2005
filing date -
Dec 28, 1999
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Abstract
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula I:Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-α expression utilizing compounds of the present invention are also disclosed.
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