Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof
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United States of America Patent
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Jan 27, 2009
Grant Date -
Aug 10, 2006
app pub date -
Jan 30, 2004
filing date -
Jan 31, 2003
priority date (Note) -
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Abstract
Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″-amide derivative of the formula (II)and a caprazene-1′″-ester derivative of the formula (III)from caprazene. Further, there could be synthesized a caprazol-1′″-amide derivative of the formula (V)and a caprazol-1′″-amide-3′″-ester derivative and a caprazol-3′″-ester derivative, etc. from caprazol. Furthermore, an imidazolidinone derivative could be synthesized from the ring-opened product of the 1,4-diazepinone ring of caprazol.The novel caprazene derivative, novel caprazol derivative and novel imidazolidinone derivative now synthesized exhibit excellent antibacterial activities against a variety of bacteria, including acid-fast bacteria.
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