Method of inhibition of vascular development using an antibody

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United States of America Patent

PATENT NO 7485297
APP PUB NO 20060057138A1
SERIAL NO

11199739

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.

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Patent Owner(s)

Patent OwnerAddress
TAKEDA PHARMACEUTICAL COMPANY LIMITED1-1 DOSHOMACHI 4-CHOME CHUO-KU OSAK-SHI OSAKA 541-0045 541-0045

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dransfield, Daniel T Hanson , US 43 449
Hoet, Rene Maastricht , NL 40 582
Hufton, Simon E Clitheroe , GB 17 420
Pieters, Henk Maastricht , NL 10 204
Wood, Clive R Cambridge , US 33 2286

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