Biosensors based on directed assembly of particles
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United States of America Patent
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Feb 3, 2009
Grant Date -
Jan 8, 2009
app pub date -
Jan 13, 2004
filing date -
Jan 13, 2004
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Abstract
A sensor system for detecting an effector or cofactor comprises (a) a nucleic acid enzyme; (b) a substrate for the nucleic acid enzyme, comprising a first polynucleotide; (c) a first set of particles comprising a second polynucleotide at least partially complementary to the substrate, where the polynucleotide is attached to the particles at its 3′ terminus; and (d) a second set of particles comprising a third polynucleotide at least partially complementary to the substrate, where the polynucleotide is attached to the particles at its 5′ terminus.
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