Solid-phase reactions
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United States of America Patent
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Feb 3, 2009
Grant Date -
Jun 26, 2003
app pub date -
Jul 17, 2002
filing date -
Jul 17, 2001
priority date (Note) -
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Abstract
The present invention relates to systems, compositions, and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for attaching nucleic acids to solid supports and modifying nucleic acids. For example, in some embodiments, the 5′ nuclease activity of a cleavage agent is used to cleave a cleavage structure formed on the solid support, the occurrence of the cleavage event indicating the presence of specific nucleic acid sequences.
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