Control of drug release by transient modification of local microenvironments
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United States of America Patent
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Feb 10, 2009
Grant Date -
Aug 3, 2006
app pub date -
Jan 25, 2006
filing date -
Jan 25, 2005
priority date (Note) -
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status (Latency Note)
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Abstract
Methods, formulations, and devices are provided for enhancing drug delivery from a medical device. The method is provided for increasing the rate or quantity of a drug formulation released from an implantable drug delivery device, which method comprises the step of providing a release-modifying agent within or proximate to the implantable drug delivery device, in a manner effective to inhibit gelation, aggregation, or precipitation of the drug formulation being released from the device. The drug formulation and the release-modifying agent may be stored together in at least one reservoir in the implantable drug deliver device. Alternatively, the release-modifying agent may be stored in one or more reservoirs separate from the drug formulation.
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