US Patent No: 7,491,393
Number of patents in Portfolio can not be more than 2000
Methods of inhibiting IL-2 production by T cells by administering 7C10 and 16C10 CD80-specific antibodies
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Feb 17, 2009
Issued date -
Aug 17, 2007
filing date -
11/840,594
serial no -
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Abstract
The present invention relates to the identification of antibodies which are specific to human B7.1 antigen (CD80) and which are capable of inhibiting the binding of B7.1 to a CD28 receptor and which are not capable of inhibiting the binding of B7.1 to a CTLA-4 receptor. Two of these antibodies, 16C10 and 7C10, significantly inhibit the production of IL-2, in spite of the existence of a second activating ligand B7.2 (CD86). Blocking of the primary activation signal between CD28 and B7.1 (CD80) with these antibodies while allowing the unimpaired or coincident interaction of CTLA-4 and B7.1 and/or B7.2 represents a combined antagonistic effect on positive co-stimulation with an agonistic effect on negative signalling. These antibodies may be used as specific immunosuppressants, e.g., for the treatment of autoimmune diseases and to prevent organ transplant rejection.
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First Claim
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 5,770,197 Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules | 81 | 1993 | |
| 5,434,131 Chimeric CTLA4 receptor and methods for its use | 130 | 1993 | |
| 5,521,288 CD28IG fusion protein | 83 | 1994 | |
| 5,580,756 B7IG fusion protein | 70 | 1994 | |
| 5,844,095 CTLA4 Ig fusion proteins | 90 | 1995 | |
| 5,885,579 CTLA4 receptor and uses thereof | 35 | 1997 | |
| 6,051,228 Antibodies against human CD40 | 41 | 1998 | |
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| 6,113,898 Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies | 32 | 1995 | |
| 6,709,654 Treatment of psoriasis using anti-B7.1 (CD80) antibodies | 9 | 1999 | |
| 6,893,638 Methods for treating b cell lymphoma using CD80-specific antibodies | 9 | 2001 | |
| 7,153,508 Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4 | 8 | 2002 | |
| 7,192,585 CD80 specific antibodies | 8 | 2005 | |
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| 4,816,567 Recombinant immunoglobin preparations | 1314 | 1983 | |
| 5,116,964 Hybrid immunoglobulins | 433 | 1989 | |
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| 4,816,397 Multichain polypeptides or proteins and processes for their production | 416 | 1984 | |
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| 5,747,034 Methods and materials for the induction of T cell anergy | 35 | 1994 | |
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| 6,162,432 Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction | 22 | 1995 | |
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| 5,304,635 Antigen specifically expressed on the surface of B cells and Hodgkin's cells | 15 | 1992 | |
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