Evolving new molecular function
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United States of America Patent
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Feb 17, 2009
Grant Date -
Sep 16, 2004
app pub date -
Aug 19, 2003
filing date -
Aug 19, 2002
priority date (Note) -
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Abstract
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.
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