Inhibitors of serine proteases, particularly hepatitis C virus NS3 protease
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Feb 24, 2009
Grant Date -
Dec 25, 2003
app pub date -
Mar 19, 2003
filing date -
Apr 3, 2000
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to compounds that are useful as protease inhibitors, particularly as serine protease inhibitors, and more particularly as hepatitis C NS3 protease inhibitors. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HCV NS3 protease activity and consequently, may be advantageously used as therapeutic agents against the hepatitis C virus and other viruses that are dependent upon a serine protease for proliferation. This invention also relates to methods for inhibiting the activity of proteases, including hepatitis C virus NS3 protease and other serine proteases, using the compounds of this invention and related compounds.
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