Human antibodies specific to KDR and uses thereof
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United States of America Patent
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Mar 3, 2009
Grant Date -
Oct 20, 2005
app pub date -
Mar 4, 2003
filing date -
Mar 4, 2002
priority date (Note) -
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Abstract
The invention provides an antibodies that bind to KDR with an affinity comparable to or higher than human VEGF, and that neutralizes activation of KDR. Antibodies include whole immunoglobulins, monovalent Fabs and single chain antibodies, multivalent single chain antibodies, diabodies, triabodies, and single domain antibodies. The invention further provides nucleic acids and host cells that encode and express these antibodies. The invention further provides a method of neutralizing the activation of KDR, a method of inhibiting angiogenesis in a mammal and a method of inhibiting tumor growth in a mammal.
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