Aerosol formulations and aerosol delivery of buprenorphine
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United States of America Patent
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Mar 10, 2009
Grant Date -
Aug 5, 2004
app pub date -
Dec 15, 2003
filing date -
Feb 4, 2003
priority date (Note) -
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Abstract
A liquid aerosol formulation comprising at least one thermally stable active ingredient selected from the group consisting of buspirone, buprenorphine, triazolam, cyclobenzaprine, zolpidem, pharmaceutically acceptable salts and esters thereof and derivatives thereof. The liquid formulation can include an organic solvent such as propylene glycol and one or more optional excipients. The active ingredient can be present in an amount of 0.01 to 5 wt. % and the formulation can be heated to provide a vapor which forms an aerosol having a mass median aerodynamic diameter of less than 3 μm.
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