Polymerases for analyzing or typing polymorphic nucleic acid fragments and uses thereof
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United States of America Patent
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Mar 10, 2009
Grant Date -
Nov 14, 2002
app pub date -
Jun 27, 2001
filing date -
Feb 7, 1997
priority date (Note) -
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Abstract
polymerases or mutants or derivatives thereof, whereby minisatellite, microsatellite or STR DNA molecules may be amplified and analyzed for polymorphisms. The invention also relates to polymerases having reduced, substantially reduced or eliminated ability to add non-template 3′ nucleotides to a synthesized nucleic acid molecule. In accordance with the invention, such reduction or elimination may be accomplished by modifying or mutating the desired polymerase.
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