US Patent No: 7,501,509

Number of patents in Portfolio can not be more than 2000

Water soluble tetrapyrollic photosensitizers for photodynamic therapy

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ALSO PUBLISHED AS: 20070149497
ATTORNEY / AGENT: (SPONSORED)
 

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Abstract

group or esters thereof said tetrapyrollic compound being a chlorin, bacteriochlorin, porphyrin, pyropheophorbide, purpurinimide, or bacteriopurpurinimide. Desirably the compound has the formula:. The invention also includes a method of treatment by photodynamic therapy by treatment with light after injecting the compound and a method of imaging by fluorescence after injection of the compound.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
HEALTH RESEARCH, INC.BUFFALO, NY240

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Goswami, Lalit Amherst, NY 8 3
Gryshuk, Amy Pleasanton, CA 8 3
Oseroff, Allan Buffalo, NY 18 62
Pandey, Ravindra K Williamsville, NY 56 486
Potter, William Stampleford, GB 13 4

Cited Art

Patent Info (Count) # Cites Year
 
HEALTH RESEARCH, INC. (36)
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5,002,962 Photosensitizing agents 50 1988
4,932,934 Methods for treatment of tumors 78 1988
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5,111,821 Fluorometric method for detecting abnormal tissue using dual long-wavelength excitation 22 1988
5,171,741 Bacteriochlorophyll-a derivatives useful in photodynamic therapy 45 1989
4,968,715 Use of purified hematoporphyrin trimers in photodynamic therapy 36 1989
5,028,621 Drugs comprising porphyrins 35 1989
5,074,632 Fiber optic diffusers and methods for manufacture of the same 51 1990
5,062,431 In vivo fluorescence photometer 49 1990
5,219,345 Backscatter monitoring system 23 1990
5,015,463 Method to diagnose the presence or absence of tumor tissue 24 1990
5,190,966 Purified hematoporphyrin dimers and trimers useful in photodynamic therapy 31 1990
5,093,349 Photosensitizing agents 44 1990
5,145,863 Method to destroy or impair target cells 33 1990
5,173,504 Bacteriochlorophyll-a derivatives useful in photodynamic therapy 38 1991
5,225,433 Treatment of tumors using chlorins 25 1991
5,205,291 In vivo fluorescence photometer 53 1991
5,198,460 Pyropheophorbides and their use in photodynamic therapy 48 1992
5,190,536 Submersible lens fiberoptic assembly for use in PDT treatment 38 1992
5,257,970 In situ photodynamic therapy 48 1992
5,314,905 Pyropheophorbides conjugates and their use in photodynamic therapy 50 1992
5,403,308 Submersible lens fiberoptic assembly for use in PDT treatment 15 1992
5,459,159 Pyropheophorbides and their use in photodynamic therapy 38 1994
5,770,730 Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer 22 1996
5,671,317 Fiber optic positioner 16 1996
5,864,035 Synthesis of isoimide of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer 21 1997
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6,084,717 Laser beam splitter 14 1999
6,624,187 Long wave length absorbing bacteriochlorin alkyl ether analogs 15 2000
6,534,040 Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals 18 2000
6,495,585 Method for treating hyperproliferative tissue in a mammal 10 2001
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7,053,210 Efficient synthesis of pyropheophorbide a and its derivatives 3 2003
 
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5,814,008 Method and device for applying hyperthermia to enhance drug perfusion and efficacy of subsequent light therapy 58 1996
5,715,837 Transcutaneous electromagnetic energy transfer 81 1996
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6,080,160 Use of shape memory alloy for internally fixing light emitting device at treatment site 49 1996
5,782,896 Use of a shape memory alloy to modify the disposition of a device within an implantable medical probe 72 1997
5,876,427 Compact flexible circuit configuration 44 1997
5,997,569 Flexible and adjustable grid for medical therapy 19 1997
5,827,186 Method and PDT probe for minimizing CT and MRI image artifacts 61 1997
5,865,840 Enhancement of light activation effect by immune augmentation 16 1997
6,416,531 Application of light at plural treatment sites within a tumor to increase the efficacy of light therapy 21 1998
6,096,066 Conformal patch for administering light therapy to subcutaneous tumors 44 1998
6,344,050 Use of pegylated photosensitizer conjugated with an antibody for treating abnormal tissue 35 1998
6,454,789 Patient portable device for photodynamic therapy 39 1999
6,273,904 Polymer battery for internal light device 43 1999
6,602,274 Targeted transcutaneous cancer therapy 45 1999
6,210,425 Combined imaging and PDT delivery system 53 1999
6,238,426 Real-time monitoring of photodynamic therapy over an extended time 17 1999
2003/0114,434 EXTENDED DURATION LIGHT ACTIVATED CANCER THERAPY 17 1999
6,319,273 Illuminating device for treating eye disease 61 1999
6,281,611 Use of moving element to produce heat 15 2000
6,331,744 Contactless energy transfer apparatus 54 2000
6,899,723 Transcutaneous photodynamic treatment of targeted cells 29 2001
2002/0127,230 Noninvasive vascular therapy 16 2001
6,554,853 Use of pegylated photosensitizer conjugated with an antibody for treating abnormal tissue 16 2001
6,657,351 Contactless energy transfer apparatus 24 2001
6,986,782 Ambulatory photodynamic therapy 21 2002
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LIGHT SCIENCES CORPORATION (14)
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6,138,681 Alignment of external medical device relative to implanted medical device 38 1997
5,945,762 Movable magnet transmitter for inducing electrical current in an implanted coil 44 1998
5,997,842 Radionuclide excited phosphorescent material for administering PDT 17 1998
6,092,531 Movable magnet transmitter for inducing electrical current in an implanted coil 23 1999
2002/0049,247 Novel treatment for eye disease 32 2001
2003/0018,371 Compositions and methods for the treatment of metabolic bone disorders and bone metastases 12 2001
2003/0030,342 Contactless energy transfer apparatus 30 2001
2002/0127,224 Use of photoluminescent nanoparticles for photodynamic therapy 70 2002
2003/0109,813 Energy-activated targeted cancer therapy 12 2002
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5,697,902 Method for imaging and treating organs and tissues 70 1995
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5,776,094 Method and kit for imaging and treating organs and tissues 35 1995
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6,096,289 Intraoperative, intravascular, and endoscopic tumor and lesion detection, biopsy and therapy 51 1998
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6,387,350 Intraoperative, intravascular and endoscopic tumor and lesion detection, biopsy and therapy 26 1999
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (7)
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5,591,847 Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages 25 1994
6,406,297 Salicylamide-lanthanide complexes for use as luminescent markers 16 2000
6,515,113 Phthalamide lanthanide complexes for use as luminescent markers 19 2000
 
THE UNIVERSITY OF BRITISH COLUMBIA (6)
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5,705,518 Method of activating photosensitive agents 32 1995
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5,831,088 Methods to prepare .beta..beta.'-dihydroxy meso-substituted chlorins, isobacteriochlorins and bacteriochlorins 14 1997
 
GE HEALTHCARE AS (5)
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6,264,914 Contrast agents 25 1999
6,350,431 Compounds 31 1999
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THE GENERAL HOSPITAL CORPORATION (5)
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5,556,612 Methods for phototherapeutic treatment of proliferative skin diseases 59 1994
5,824,080 Photochemistry for the preparation of biologic grafts--allografts and xenografts 27 1996
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6,107,466 Acceleration of wound healing by photodynamic therapy 20 1998
 
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5,580,896 Treatment of pain and colorectal cancer with dipeptoids of .alpha.-substituted Trp-Phe derivatives 6 1995
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Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
HEALTH RESEARCH, INC. (2)
8,133,473 conjugates for MR contrast media and radiopharmaceuticals 0 2006
7,897,140 Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents 0 2006

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