Methods for enhancing antigen-specific immune response using antibodies that bind OX-40
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United States of America Patent
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Mar 17, 2009
Grant Date -
May 9, 2002
app pub date -
Sep 4, 2001
filing date -
Feb 24, 1998
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Abstract
Compositions and methods for enhancing the immune response of a mammal to an antigen by engaging the OX-40 receptor on the surface of T-cells are disclosed, comprising administering to the mammal a composition comprising a purified antibody that specifically binds the OX-40 receptor and a pharmaceutically acceptable carrier, wherein said composition is administered to the mammal such that the antibody that specifically binds the OX-40 receptor is presented to T-cells of the mammal during or shortly after priming of the T-cells by the antigen. Such compositions and methods can be used in immunization and cancer treatment.
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