Process for constructing strain having compactin hydroxylation ability
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United States of America Patent
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Mar 17, 2009
Grant Date -
Aug 3, 2006
app pub date -
Dec 5, 2005
filing date -
Dec 3, 2004
priority date (Note) -
Expired
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Abstract
The present invention is directed to methods and compositions for microbial based production of pravastatin. The compositions of the invention include novel strains of microorganisms that are capable of efficiently hydroxylating compactin (ML-236 B) resulting in production of pravastatin. In particular, the microorganisms of the invention are genetically engineered to express both cytochrome P-450 and the fdxshe or fdxshe-like protein. The invention further relates to the use of such microorganisms in processes designed for production of pravastatin for use in treatment of disease such as hypercholesterolemia and hyperlipidemia.
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