US Patent No: 7,510,702

Number of patents in Portfolio can not be more than 2000

Delivery of nonsteroidal antiinflammatory drugs through an inhalation route

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ALSO PUBLISHED AS: 20060269487
ATTORNEY / AGENT: (SPONSORED)
 

Importance

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Abstract

The present invention relates to the delivery of nonsteroidal antiinflammatory drugs (NSAIDs) through an inhalation route. Specifically, it relates to aerosols containing NSAIDs that are used in inhalation therapy. In a method aspect of the present invention, an NSAID is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of an NSAID, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particle having less than 5% NSAID degradation products. In a kit aspect of the present invention, a kit for delivering an NSAID through an inhalation route is provided which comprises: a) a coating of an NSAID composition and b) a device for dispensing said coating as a condensation aerosol.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ALEXZA PHARMACEUTICALS, INC.PALO ALTO, CA113

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rabinowitz, Joshua D Mountain View, CA 158 4467
Zaffaroni, Alejandro C Atherton, CA 120 3736

Cited Art

Patent Info (Count) # Cites Year
 
ALEXZA PHARMACEUTICALS, INC. (121)
2003/0051,728 Method and device for delivering a physiologically active compound 46 2001
2003/0062,042 Aerosol generating method and device 89 2001
2003/0015,196 Aerosol forming device for use in inhalation therapy 93 2002
2003/0015,197 Method of forming an aerosol for inhalation delivery 45 2002
2003/0209,240 Method and apparatus for vaporizing a compound 85 2002
6,682,716 Delivery of aerosols containing small particles through an inhalation route 47 2002
6,737,042 Delivery of drug esters through an inhalation route 42 2002
6,780,399 Delivery of stimulants through an inhalation route 43 2002
6,797,259 Delivery of muscle relaxants through an inhalation route 42 2002
6,805,853 Delivery of diazepam through an inhalation route 42 2002
6,783,753 Delivery of antidepressants through an inhalation route 42 2002
6,855,310 Delivery of analgesics through an inhalation route 44 2002
6,716,415 Delivery of sedative-hypnotics through an inhalation route 41 2002
6,780,400 Delivery of antiemetics through an inhalation route 44 2002
6,716,416 Delivery of antipsychotics through an inhalation route 43 2002
6,740,307 Delivery of .beta.-blockers through an inhalation route 43 2002
6,743,415 Delivery of anti-migraine compounds through an inhalation route 41 2002
6,814,954 Delivery of compounds for the treatment of Parkinsons through an inhalation route 42 2002
2003/0032,638 Delivery of benzodiazepines through an inhalation route 110 2002
6,740,308 Delivery of antihistamines through an inhalation route 42 2002
6,776,978 Delivery of opioids through an inhalation route 48 2002
6,884,408 Delivery of diphenhydramine through an inhalation route 47 2002
6,737,043 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 44 2002
6,759,029 Delivery of rizatriptan and zolmitriptan through an inhalation route 41 2002
6,803,031 Delivery of erectile dysfunction drugs through an inhalation route 52 2002
6,805,854 Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route 40 2002
6,716,417 Delivery on nonsteroidal antiinflammatory drugs through an inhalation route 42 2002
6,740,309 Delivery of compounds for the treatment of migraine through an inhalation route 41 2002
6,814,955 Delivery of physiologically active compounds through an inhalation route 40 2002
2003/0118,512 Volatilization of a drug from an inclusion complex 44 2002
2003/0131,843 Open-celled substrates for drug delivery 42 2002
7,078,016 Delivery of caffeine through an inhalation route 43 2002
2004/0009,128 Delivery of drug amines through an inhalation route 87 2003
2004/0099,266 Inhalation device for producing a drug aerosol 45 2003
2007/0028,916 Rapid-heating drug delivery article and method of use 36 2003
2007/0031,340 Thin-film drug delivery article and method of use 40 2003
2004/0096,402 Delivery of aerosols containing small particles through an inhalation route 90 2003
2004/0105,818 Diuretic aerosols and methods of making and using them 89 2003
2004/0101,481 Acute treatment of headache with phenothiazine antipsychotics 82 2003
2004/0102,434 Method for treating pain with loxapine and amoxapine 41 2003
2004/0105,819 Respiratory drug condensation aerosols and methods of making and using them 85 2003
7,090,830 Drug condensation aerosols and kits 50 2003
7,005,121 Delivery of compounds for the treatment of migraine through an inhalation route 40 2003
7,008,615 Delivery of anti-migraine compounds through an inhalation route 40 2003
7,018,619 Delivery of alprazolam, estazolam midazolam or triazolam through an inhalation route 45 2003
7,029,658 Delivery of antidepressants through an inhalation route 40 2003
7,070,761 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route 42 2003
7,070,762 Delivery of analgesics through an inhalation route 44 2003
7,078,017 Delivery of sedative-hypnotics through an inhalation route 40 2003
7,078,018 Delivery of opioids through an inhalation route 44 2003
7,078,019 Delivery of drug esters through an inhalation route 45 2003
7,078,020 Delivery of antipsychotics through an inhalation route 41 2003
7,094,392 Delivery of antihistamines through an inhalation route 40 2003
7,115,250 Delivery of erectile dysfunction drugs through an inhalation route 40 2003
7,045,118 Delivery of compounds for the treatment of migraine through an inhalation route 40 2004
7,060,254 Delivery of antidepressants through an inhalation route 40 2004
7,070,763 Delivery of diphenhydramine through an inhalation route 40 2004
7,070,764 Delivery of analgesics through an inhalation route 44 2004
7,087,216 Delivery of sedative-hypnotics through an inhalation route 40 2004
7,087,217 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route 40 2004
7,052,679 Delivery of antipsychotics through an inhalation route 41 2004
7,060,255 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 42 2004
7,063,830 Delivery of anti-migraine compounds through an inhalation route 40 2004
7,063,831 Delivery of erectile dysfunction drugs through an inhalation route 40 2004
7,067,114 Delivery of antihistamines through an inhalation route 40 2004
7,070,765 Delivery of drug esters through an inhalation route 46 2004
7,169,378 Delivery of opioids through an inhalation route 45 2004
7,033,575 Delivery of physiologically active compounds through an inhalation route 40 2004
7,070,766 Delivery of physiologically active compounds through an inhalation route 40 2004
7,018,620 Delivery of beta-blockers through an inhalation route 40 2004
7,048,909 Delivery of beta-blockers through an inhalation route 40 2004
7,005,122 Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route 40 2004
7,011,819 Delivery of rizatriptan or zolmitriptan through an inhalation route 40 2004
7,014,840 Delivery of sumatriptan, frovatriptan or naratriptan through an inhalation route 40 2004
7,018,621 Delivery of rizatriptan or zolmitriptan through an inhalation route 40 2004
7,045,119 Delivery of diazepam through an inhalation route 41 2004
7,087,218 Delivery of diazepam through an inhalation route 41 2004
7,014,841 Delivery of antiemetics through an inhalation route 40 2004
7,022,312 Delivery of antiemetics through an inhalation route 40 2004
7,063,832 Delivery of muscle relaxants through an inhalation route 40 2004
7,108,847 Delivery of muscle relaxants through an inhalation route 40 2004
6,994,843 Delivery of stimulants through an inhalation route 41 2004
7,008,616 Delivery of stimulants through an inhalation route 39 2004
7,011,820 Delivery of compounds for the treatment of Parkinsons through an inhalation route 41 2004
7,052,680 Delivery of compounds for the treatment of Parkinsons through an inhalation route 40 2004
2004/0234,699 Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same 45 2004
2004/0234,914 Percussively ignited or electrically ingnited self-contained heating unit and drug-supply unit employing same 44 2004
2004/0234,916 Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same 42 2004
2005/0079,166 Self-contained heating unit and drug-supply unit employing same 42 2004
2005/0258,159 Stable initiator compositions and igniters 30 2004
2005/0268,911 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 48 2004
2005/0034,723 Substrates for drug delivery device and methods of preparing and use 43 2004
2005/0037,506 Methods of determining film thicknesses for an aerosol delivery article 39 2004
2006/0032,496 Inhalation actuated percussive ignition system 42 2004
2006/0032,501 Aerosol drug delivery device incorporating percussively activated heat packages 43 2004
2005/0126,562 Treatment of breakthrough pain by drug aerosol inhalation 42 2004
2005/0131,739 Methods for monitoring severity of panic attacks and other rapidly evolving medical events in real time 44 2004
2006/0120,962 Cardiac safe, rapid medication delivery 43 2005
2006/0193,788 Acute treatment of headache with phenothiazine antipsychotics 43 2006
2006/0153,779 Delivery of stimulants through an inhalation route 32 2006
2006/0233,717 Delivery of compounds for the treatment of headache through an inhalation route 35 2006
2006/0177,382 Delivery of antiemetics through an inhalation route 32 2006
2006/0216,243 Delivery of Beta-Blockers Through An Inhalation Route 34 2006
2006/0216,244 Delivery of compounds for the treatment of parkinson's through an inhalation route 34 2006
2006/0233,718 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 36 2006
2006/0233,719 Delivery of antidepressants through an inhalation route 34 2006
2006/0239,936 Delivery of anti-migraine compounds through an inhalation route 34 2006
2006/0246,011 Delivery of diphenhydramine through an inhalation route 36 2006
2006/0246,012 Delivery of physiologically active compounds through an inhalation route 35 2006
2006/0251,587 Delivery of analgesics through an inhalation route 36 2006
2006/0251,588 Delivery of erectile dysfunction drugs through an inhalation route 32 2006
2006/0257,328 Delivery of caffeine through an inhalation route 35 2006
2006/0257,329 Delivery of drug esters through an inhalation route 42 2006
2006/0280,692 Delivery of antipsychotics through an inhalation route 41 2006
2006/0269,486 Delivery of diazepam through an inhalation route 34 2006
2006/0286,042 Delivery of sedative-hypnotics through an inhalation route 33 2006
2006/0286,043 Delivery of antihistamines through an inhalation route 35 2006
2007/0014,737 Delivery of muscle relaxants through an inhalation route 37 2006
2007/0178,052 DELIVERY OF OPIOIDS THROUGH AN INHALATION ROUTE 26 2007
2007/0140,982 Diuretic Aerosols and Methods of Making and Using Them 41 2007
2007/0286,816 Drug and excipient aerosol compositions 27 2007
 
ARADIGM CORPORATION (9)
5,544,646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 191 1994
5,724,957 Intrapulmonary delivery of narcotics 137 1995
5,957,124 Dynamic particle size control for aerosolized drug delivery 162 1995
5,694,919 Lockout device for controlled release of drug from patient-activated dispenser 153 1995
5,915,378 Creating an aerosolized formulation of insulin 135 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 173 1995
5,960,792 Device for aerosolized delivery of peptide drugs 165 1995
5,735,263 Lockout device for controlled release of drug from patient-activated dispenser 167 1996
6,131,570 Temperature controlling device for aerosol drug delivery 147 1998
 
R. J. REYNOLDS TOBACCO COMPANY (9)
4,708,151 Pipe with replaceable cartridge 129 1986
4,819,665 Aerosol delivery article 107 1987
4,924,883 Smoking article 99 1987
5,042,509 Method for making aerosol generating cartridge 96 1987
4,917,119 Drug delivery article 125 1988
4,941,483 Aerosol delivery article 123 1989
5,099,861 Aerosol delivery article 117 1990
5,135,009 Smokable article 111 1990
5,388,574 Aerosol delivery article 136 1993
 
PHILIP MORRIS INCORPORATED (4)
5,060,671 Flavor generating article 177 1989
5,224,498 Electrically-powered heating element 114 1991
5,345,951 Smoking article 94 1992
5,666,977 Electrical smoking article using liquid tobacco flavor medium delivery system 113 1994
 
PHILIP MORRIS USA INC. (3)
5,743,251 Aerosol and a method and apparatus for generating an aerosol 171 1996
6,234,167 Aerosol generator and methods of making and using an aerosol generator 154 1998
6,701,922 Mouthpiece entrainment airflow control for aerosol generators 95 2001
 
ALLIANCE PHARMACEUTICAL CORP. (2)
5,874,481 Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents 94 1995
6,041,777 Methods and apparatus for closed-circuit ventilation therapy 166 1995
 
BOC GROUP PLC, THE (2)
5,146,915 Anesthetic vaporizers 98 1991
5,592,934 Anaesthetic vaporizer 97 1994
 
LIPOSOME TECHNOLOGY, INC. (2)
4,895,719 Method and apparatus for administering dehydrated liposomes by inhalation 270 1987
5,049,389 Novel liposome composition for the treatment of interstitial lung diseases 154 1989
 
PFIZER INC. (2)
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6,506,762 Certain alkylene diamine-substituted heterocycles 97 2000
 
PHILIP MORRIS PRODUCTS INC. (2)
5,144,962 Flavor-delivery article 157 1989
5,649,554 Electrical lighter with a rotatable tobacco supply 97 1995
 
THE PENN STATE RESEARCH FOUNDATION (2)
5,855,913 Particles incorporating surfactants for pulmonary drug delivery 215 1997
6,136,295 Aerodynamically light particles for pulmonary drug delivery 139 1998
 
ACRUX DDS PTY LTD. (1)
6,299,900 Dermal penetration enhancers and drug delivery systems involving same 107 1998
 
ADVANCED INHALATIONS REVOLUTIONS, INC. (1)
6,095,153 Vaporization of volatile materials 150 1998
 
ALEXZA MOLECULAR DELIVERY CORPORATION (1)
2003/0138,508 Method for administering an analgesic 42 2002
 
ALFRED UNIVERSITY (1)
5,366,770 Aerosol-plasma deposition of films for electronic cells 116 1993
 
ATHENA NEUROSCIENCES, INC. (1)
6,241,969 Aqueous compositions containing corticosteroids for nasal and pulmonary delivery 127 1998
 
B.S.D. BIO SCIENCE DEVELOPMENT SNC DI OMINI C. & ZUCCARI G. (1)
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BATTELLE MEMORIAL INSTITUTE (1)
5,511,726 Nebulizer device 163 1993
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (1)
6,632,047 Heater element for use in an in situ thermal desorption soil remediation system 103 2001
 
BOWEN, JOHN, G., VALLEY VIEW COTTAGE, NEWGROUNDS, GODSHILL, FORDINGBRIDGE, HAMPSHIRE, ENGLAND (1)
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CIVITAS THERAPEUTICS, INC. (1)
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DRAGERWERK AKTIENGESELLSCHAFT (1)
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EMLIN BIOSCIENCES, LLC (1)
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ENERGY, UNITED STATES DEPARTMENT OF (1)
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GLAXOSMITHKLINE LLC (1)
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INJET DIGITAL AEROSOLS LIMITED (1)
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INSTRUMENTARIUM OY (1)
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IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (1)
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JAPAN TOBACCO INC. (1)
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KOKUSAI SEMICONDUCTOR EQUIPMENT CORPORATION (1)
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MACDONALD; ANGUS COLLINGWOOD (1)
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MAQUET CRITICAL CARE AB (1)
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NARYX PHARMA, INC. (1)
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NICO PUFF CORPORATION (1)
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NOVARTIS PHARMA AG (1)
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NUVO RESEARCH INC. (1)
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PENWEST PHARMACEUTICALS CO. (1)
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PLANTORGAN WERK HEINRICH G.E. CHRISTENSEN KG (1)
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QDOSE LIMITED (1)
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RECKITT BENCKISER LLC (1)
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RIVAL COMPANY, THE (1)
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THE PROCTER & GAMBLE COMPANY (1)
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OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (9)
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4,474,191 Tar-free smoking devices 145 1982
4,848,374 Smoking device 126 1988
5,819,756 Smoking or inhalation device 96 1996
6,591,839 Filter material for reducing harmful substances in tobacco smoke 107 2001
2003/0004,142 Use of NSAIDs for prevention and treatment of cellular abnormalities of the lung or bronchial pathway 96 2002
2007/0122,353 Drug condensation aerosols and kits 39 2006
2009/0132,648 CONTENT DELIVERY AND GLOBAL TRAFFIC MANAGEMENT NETWORK SYSTEM 2009

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ALEXZA PHARMACEUTICALS, INC. (6)
7,645,442 Rapid-heating drug delivery article and method of use 3 2003
7,834,295 Printable igniters 1 2008
8,173,107 Delivery of antipsychotics through an inhalation route 0 2009
8,074,644 Method of forming an aerosol for inhalation delivery 0 2009
8,333,197 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 0 2009
8,387,612 Self-contained heating unit and drug-supply unit employing same 0 2009

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
7.5 Year Payment $3600.00 $1800.00 $900.00 Sep 30, 2016
11.5 Year Payment $7400.00 $3700.00 $1850.00 Sep 30, 2020
Fee Large entity fee small entity fee micro entity fee
Surcharge - 7.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00