Anticancer drug-chitosan complex forming self-aggregates and preparation method thereof
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United States of America Patent
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Mar 31, 2009
Grant Date -
Jul 15, 2004
app pub date -
Aug 14, 2002
filing date -
Aug 18, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to an anticancer drug-chitosan complex forming self-aggregates and the preparation method thereof. More precisely, the present invention relates to the anticancer drug-chitosan complex forming self-aggregates in aqueous media composed of a hydrophobic anticancer agent and a hydrophilic chitosan, and the preparation method thereof. The anticancer drug-chitosan complex of the present invention not only works selectively against target tumor tissue but also continues to release the medicine over a long period of time. Besides, the anticancer drug-chitosan complex could have greater amount of drug by adding the anticancer drug into self-aggregates, which is generally limited by chemical bond. Therefore, the anticancer drug-chitosan complex of the present invention can be effectively used for the cancer chemotherapy.
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