Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
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United States of America Patent
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Apr 7, 2009
Grant Date -
Jun 24, 2004
app pub date -
May 30, 2003
filing date -
Jun 1, 2001
priority date (Note) -
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Abstract
Modified antibodies, or antigen-binding fragments thereof, to the extracellular domain of human prostate specific membrane antigen (PSMA) are provided. The modified anti-PSMA antibodies, or antigen-binding fragments thereof, have been rendered less immunogenic compared to their unmodified counterparts to a given species, e.g., a human. Pharmaceutical compositions including the aforesaid antibodies, nucleic acids, recombinant expression vectors and host cells for making such antibodies and fragments are also disclosed. Methods of using the antibodies of the invention to detect human PSMA, or to ablate or kill a PSMA-expressing cell, e.g., a PSMA-expressing cancer or prostatic cell, either in vitro or in vivo, are also provided.
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