Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 7520278
APP PUB NO 20050126569A1
SERIAL NO

11043363

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention includes dry powder inhalers for dispensing and/or holding inhalant formulated dry powder substances and associated fabrication and dispensing methods that can employ an amplitude modulated non-linear signal comprising a plurality of superimposed frequencies, the frequencies corresponding to a priori flow characteristic frequencies of the dry powder being dispensed. The present invention also includes pocket-sized inhalers with an elastomeric flexible pivoting cover.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ORIEL THERAPEUTICS, INC.DURHAM, NC38

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Crowder, Timothy M Durham, US 11 308
Hickey, Anthony J Chapel Hill, US 16 336
Warden, Jeffrey A Chapel Hill, US 6 362

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Minnesota Mining and Manufacturing Company (3)
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6012454 Dry powder inhalation device 62 1997
 
Other [Check patent profile for assignment information] (5)
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5349947 Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow 154 1993
5482030 Aerosol and non-aerosol spray counter 150 1994
5583304 Apparatus and method for testing powder properties 18 1995
5699789 Dry powder inhaler 73 1996
 
ORIEL THERAPEUTICS, INC. (3)
* 6889690 Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages 79 2003
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MEDERIO AG (1)
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KOS LIFE SCIENCES, INC. (1)
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WEATHERFORD TECHNOLOGY HOLDINGS, LLC (1)
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3M COMPANY (1)
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MICRODOSE THERAPEUTX, INC. (5)
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GLAXO WELLCOME INC. (1)
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MICRODRUG AG (1)
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SNECMA (1)
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AISAN KOGYO KABUSHIKI KAISHA (1)
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TRANSPHARMA LTD (1)
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5577497 Dry powder inhaler 116 1993
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PENNWALT CORPORATION, A PA CORP. (CHANGED TO) (1)
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FISONS LIMITED (1)
6109261 Powder inhaler with breath flow regulation valve 53 1998
 
FISONS PLC (1)
5727546 Powder inhaler with breath flow regulation valve 97 1996
 
AEA TECHNOLOGY PLC (1)
5724959 Powder inhaler with specific orifice and baffle arrangement 55 1994
 
VORTRAN MEDICAL TECHNOLOGY 1, INC. (1)
5533502 Powder inhaler with aerosolization occurring within each individual powder receptacle 106 1994
 
SARNOFF CORPORATION (4)
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5871010 Inhaler apparatus with modified surfaces for enhanced release of dry powders 20 1996
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ABRAXIS BIOSCIENCE, LLC (1)
5875776 Dry powder inhaler 197 1996
 
The United States of America as represented by the Secretary of the Navy (2)
5823434 Electromechanical driver for an aerosol dispensing apparatus which dispenses a medicated vapor into the lungs of a patient 34 1997
5938118 Electromechanical driver for an aerosol dispensing apparatus which dispenses a medicated vapor into the lungs of a patient 44 1998
 
Ministry of International Trade & Industry (1)
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ISL (R&D) LTD. (1)
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Minolta Co., Ltd. (1)
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5767068 Pure biologically active colistin, its components and a colistin formulation for treatment of pulmonary infections 19 1997
 
ZHEJIANG HISUN PHARMACEUTICAL CO., LTD. (2)
6209538 Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament 73 1998
* 6561186 Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament 64 2001
 
FREESLATE, INC. (1)
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ACKRAD LABORATORIES, INC. (1)
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APTAR FRANCE SAS (3)
5622166 Dry powder inhaler delivery system 141 1995
6029663 Dry powder inhaler delivery system 101 1997
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BATTELLE PULMONARY THERAPEUTICS, INC. (1)
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PONWELL ENTERPRISES LIMITED, A BRITISH VIRGIN ISLANDS COMPANY, C/O BYRNE TRUST COMPANY LIMITED. (1)
6196218 Piezo inhaler 215 1999
 
ETELA-HAMEEN KEUHKOVAMMAYHDISTYS R.Y. (1)
5063922 Ultrasonic atomizer 270 1989
 
Andi-Ventis Limited (1)
* 5033463 Multi-dose inhaler for medicaments in powder form 175 1990
 
SHL GROUP AB (1)
* 6880555 Inhaler 57 2002
 
RHONE-POULENC RORER LIMITED (2)
* 5797391 Inhaler 51 1993
* 5896855 Multi dose inhaler apparatus 122 1995
 
PAUL ROYALTY FUND, L.P. (1)
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UNIVERSIDAD DE SEVILLA (1)
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Dove Systems, Inc. (1)
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ASTRAZENECA AB (1)
* 6637431 Inhalation device employing blister packs with cavities and alignment slits 56 2001
 
GLAXO GROUP LIMITED (4)
4778054 Pack for administering medicaments to patients 142 1986
6143277 Metered dose inhaler for salmeterol 92 1996
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INJET DIGITAL AEROSOLS LIMITED (1)
5894841 Dispenser 357 1995
 
LANPHER DIAGNOSTIC WORKSTATIONS, INC. (1)
5363842 Intelligent inhaler providing feedback to both patient and medical professional 431 1991
 
RIKER LABORATORIES, INC. (1)
4446862 Breath actuated devices for administering powdered medicaments 102 1981
 
ARADIGM CORPORATION (63)
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5542410 Delivery of aeerosol medications for inspiration 79 1994
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5520166 Medication cassette for an automatic aerosol medication delivery system 164 1995
5718222 Disposable package for use in aerosolized delivery of drugs 120 1995
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5608647 Method for releasing controlled amount of aerosol medication 203 1995
5957124 Dynamic particle size control for aerosolized drug delivery 182 1995
5694919 Lockout device for controlled release of drug from patient-activated dispenser 210 1995
5915378 Creating an aerosolized formulation of insulin 150 1995
5934272 Device and method of creating aerosolized mist of respiratory drug 275 1995
5960792 Device for aerosolized delivery of peptide drugs 197 1995
6098620 Device for aerosolizing narcotics 80 1995
5660166 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 96 1996
5735263 Lockout device for controlled release of drug from patient-activated dispenser 215 1996
6012450 Intrapulmonary delivery of hematopoietic drug 153 1996
5823178 Disposable package for use in aerosolized delivery of drugs 99 1996
5770152 Collapsible container for measuring particles in a sample fluid 15 1996
5906202 Device and method for directing aerosolized mist to a specific area of the respiratory tract 119 1996
* 5743250 Insulin delivery enhanced by coached breathing 154 1996
5743252 Method for releasing controlled amount of aerosol medication 81 1996
5755218 Method and apparatus for releasing a controlled amount of aerosol medication over a selectable time interval 173 1996
5829436 Ventilation imaging using a fine particle aerosol generator 34 1997
5888477 Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin 69 1997
5819726 Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease 29 1997
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5910301 Method of intrapulmonary administration of a narcotic drug 54 1997
5826570 Delivery of aerosol medications for inspiration 72 1997
5813397 Delivery of aerosol medication for inspiration 126 1997
5884620 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 92 1997
5855564 Aerosol extrusion mechanism 47 1997
5792057 Ventilation imaging using a fine particle aerosol generator 42 1997
6131567 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 71 1998
6192882 Formulation and devices for monitoring the efficacy of the delivery of aerosols 52 1998
6085753 Insulin delivery enhanced by coached breathing 38 1998
6123068 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 74 1998
5873358 Method of maintaining a diabetic patient's blood glucose level in a desired range 17 1998
5970973 Method of delivering insulin lispro 64 1998
6098615 Method of reproducibly effecting a patient's glucose level 38 1998
6024090 Method of treating a diabetic patient by aerosolized administration of insulin lispro 17 1998
6131570 Temperature controlling device for aerosol drug delivery 211 1998
5941240 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 53 1998
5971951 Aerosol extrusion mechanism 80 1998
6014969 Disposable package for use in aerosolized delivery of antibiotics 44 1998
6070575 Aerosol-forming porous membrane with certain pore structure 54 1998
6288360 Excimer laser ablation process control of multilaminate materials 31 1999
6167880 Inhaled insulin dosage control delivery enhanced by controlling total inhaled volume 73 1999
6354516 Pore structures for reduced pressure aerosolization 15 1999
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6351984 Inspection method and device for non-destructive analysis of a container material 13 2000
6230706 Method and device for creating aerosol with porous membrane with certain pore structure 45 2000
6369354 Excimer laser ablation process control of multilaminate materials 10 2000
6250298 Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin 41 2000
6263872 Temperature controlling device for aerosol drug delivery 74 2000
6349719 Formulation and devices for monitoring the efficacy of the delivery of aerosols 32 2001
 
MAQUET CRITICAL CARE AB (1)
4819629 Method and apparatus for delivering aerosol to the airways and/or lungs of a patient 330 1987
 
INNOVATA BIOMED LIMITED (1)
6845772 Inhaler 24 2002
 
Consort Medical PLC (1)
6062214 Inhaler for medicament 78 1997
 
BTG INTERNATIONAL LIMITED (1)
5975076 Dry powder inhalers 22 1996
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
PROTEUS DIGITAL HEALTH, INC. (6)
9125979 Fluid transfer port information system 1 2008
8419638 Body-associated fluid transport structure evaluation devices 0 2008
9084566 Smart parenteral administration system 9 2009
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ORIEL THERAPEUTICS, INC. (2)
* 8210172 Dry powder inhalers 0 2009
* 2009/0165,790 DRY POWDER INHALERS 3 2009
 
MANNKIND CORPORATION (28)
8636001 Dry powder inhaler and system for drug delivery 34 2009
8499757 Dry powder inhaler and system for drug delivery 34 2009
8424518 Dry powder inhaler and system for drug delivery 37 2009
* 2009/0308,390 Dry Powder Inhaler and System for Drug Delivery 37 2009
* 2009/0308,392 Dry Powder Inhaler and System for Drug Delivery 32 2009
9364619 Interactive apparatus and method for real-time profiling of inhalation efforts 1 2009
8485180 Dry powder drug delivery system 39 2010
9358352 Dry powder drug delivery system and methods 1 2011
9364436 High capacity diketopiperazine microparticles and methods 0 2012
9339615 Dry powder inhaler and system for drug delivery 0 2013
8912193 Dry powder inhaler and system for drug delivery 1 2013
9393372 Dry powder drug delivery system 0 2013
9802012 Dry powder drug delivery system and methods 0 2013
9241903 Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent 0 2013
9511198 Dry powder inhaler and system for drug delivery 0 2013
9283193 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 0 2014
9630930 Diketopiperazine microparticles with defined specific surface areas 0 2014
9700690 Inhalation apparatus 0 2014
9446133 Dry powder inhaler and system for drug delivery 0 2014
9220687 Substituted diketopiperazine analogs for use as drug delivery agents 1 2014
9801925 Potentiation of glucose elimination 0 2015
9706944 Apparatus and method for simulating inhalation efforts 0 2015
9446001 Increasing drug affinity for crystalline microparticle surfaces 0 2015
9655850 Substituted diketopiperazine analogs for use as drug delivery agents 0 2015
9675674 Diketopiperazine salts for drug delivery and related methods 0 2016
9717689 Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents 0 2016
9796688 Catalysis of diketopiperazine synthesis 0 2016
9662461 Dry powder drug delivery system and methods 0 2016
 
Mankind Corporation (1)
9192675 Dry powder inhaler and system for drug delivery 0 2013
 
VECTURA DELIVERY DEVICES LIMITED (4)
* 7950389 Inhaler 8 2004
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8443798 Inhaler 3 2011
8997737 Inhaler 0 2013
 
LE LABOGROUP SAS (1)
9179691 Delivering aerosolizable food products 0 2008
 
Torrey Pines Institute for Molecular Studies (1)
9233159 Methods and compositions for treating pain 0 2012
 
TORREY PINES INSTITUTE OF MOLECULAR STUDIES (1)
9610351 Methods and compositions for treating pain 0 2015
 
ASTRAZENECA AB (2)
* 2014/0000,601 INHALER 2 2011
D716936 Inhaler 25 2012
* Cited By Examiner

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