Detection of nucleic acid sequence differences by comparative genomic hybridization
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United States of America Patent
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May 19, 2009
Grant Date -
Mar 23, 2006
app pub date -
Feb 16, 2005
filing date -
Mar 4, 1992
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Abstract
The present invention provides a method of detecting nucleotide sequence differences between two nucleic acid samples. The method employs a comparative genomic hybridization (CGH) technique to analyze the sequence differences between the samples. This method permits the identification of small sequence differences (e.g., sequence divergence of 1% or less) in nucleic acid samples of high complexity (e.g., an entire genome).
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