Enzyme-free isothermal exponential amplification of nucleic acids and nucleic acid analog signals

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United States of America Patent

PATENT NO 7538202
APP PUB NO 20050227259A1
SERIAL NO

11009386

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Abstract

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An enzyme-free, isothermal method of generating an amplification signal indicative of a target nucleic acid molecule is provided, as are compositions for performing such a method. An advantage of the detection system is that it is very sensitive, and can allow for the detection of a single target molecule in a sample.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
CALIFORNIA INSTITUTE OF TECHNOLOGYPASADENA, CA2314

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Winfree, Erik Altadena, US 6 126
Yurke, Bernard Plainfield, US 22 292
Zhang, David Overland Park, US 32 182

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Siemens Healthcare Diagnostics Products GmbH (1)
* 5914230 Homogeneous amplification and detection of nucleic acids 62 1996
 
DIAGNOSTICS FOR THE REAL WORLD, LTD. (1)
* 2004/0053,256 Detection signal and capture in dipstick assays 3 2003
 
PUBLIC HEALTH RESEARCH INSTITUTE (1)
* 5118801 Nucleic acid process containing improved molecular switch 205 1988
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
EMERALD CLOUD LAB, INC. (1)
9429547 Systems and methods for automated preparation of nucleic acids 0 2013
 
ARIOSA DIAGNOSTICS, INC. (1)
* 2012/0219,950 ASSAY SYSTEMS FOR DETECTION OF ANEUPLOIDY AND SEX DETERMINATION 5 2012
 
EMERALD THERAPEUTICS, INC. (5)
8630809 System and method for propagating information using modified nucleic acids 0 2011
9289502 Preparation of oligo conjugates 0 2013
9068218 Rotationally sequestered translators 0 2013
9547750 System and method for propagating information using modified nucleic acids 0 2013
9624495 Rotationally sequestered translators 0 2015
* Cited By Examiner

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