Microarray having a base cleavable sulfonyl linker
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United States of America Patent
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Jun 2, 2009
Grant Date -
Aug 30, 2007
app pub date -
Feb 24, 2006
filing date -
Feb 24, 2006
priority date (Note) -
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Abstract
The present invention provides a microarray having base cleavable, sulfonyl-containing linkers and a process to make the microarray. Oligonucleotides of any sequence may be synthesized on the microarray having the cleavable linker. The oligonucleotides may be cleaved and recovered as a pool of oligonucleotides having a three prime phosphate moiety. Specifically, the microarray is an electrode containing microarray, and the oligonucleotides are electrochemically synthesized.
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