Nucleic acid analysis using sequence tokens
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United States of America Patent
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Jun 9, 2009
Grant Date -
Nov 8, 2007
app pub date -
Jan 22, 2007
filing date -
Jan 23, 2006
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Abstract
The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique members of a collection of oligonucleotide tags, or sequence tokens, which, in turn, can be identified using a variety of readout platforms. As a general rule, a given sequence token is used once and only once in any tag sequence. In addition, the present invention also provides methods for using the sequence tokens to efficiently determine variations in nucleotide sequences in the associated nucleic acid sequence fragments.
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