Compositions for manipulating the lifespan and stress response of cells and organisms
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United States of America Patent
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Jun 9, 2009
Grant Date -
Jun 23, 2005
app pub date -
Jul 1, 2004
filing date -
Jul 1, 2003
priority date (Note) -
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Abstract
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.
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