HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells
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United States of America Patent
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Jun 9, 2009
Grant Date -
Sep 23, 2004
app pub date -
Mar 20, 2003
filing date -
Apr 5, 2002
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Abstract
The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds the receptor bound by peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID NO: 9). Methods of directing a conjugate of the invention to tumor blood vessels and tumor cells and of using a conjugate to treat cancer also are provided.
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