Human monoclonal antibodies to dendritic cells
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United States of America Patent
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Jul 21, 2009
Grant Date -
Sep 4, 2003
app pub date -
May 8, 2001
filing date -
May 8, 2000
priority date (Note) -
In Force
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Abstract
Isolated human monoclonal antibodies and antigen-binding portions thereof which specifically bind to dendritic cells are disclosed. Also disclosed are bispecifics, immunotoxins and antigen conjugates which include the antibodies or antibody portions. The human antibodies can be produced in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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