
US Patent No: 7,565,191
Number of patents in Portfolio can not be more than 2000
Tissue site markers for in vivo imaging
Stats
-
Jul 21, 2009
Issued date -
Sep 29, 2005
filing date -
11/238,201
serial no -
In Force
status
Importance
Abstract
The invention is directed biopsy site markers and methods of marking a biopsy site, so that the location of the biopsy cavity is readily visible by conventional imaging methods, particularly by ultrasonic imaging. The biopsy site markers of the invention have high ultrasound reflectivity, presenting a substantial acoustic signature from a small marker, so as to avoid obscuring diagnostic tissue features in subsequent imaging studies, and can be readily distinguished from biological features. The several disclosed embodiments of the biopsy site marker of the invention have a high contrast of acoustic impedance as placed in a tissue site, so as to efficiently reflect and scatter ultrasonic energy, and preferably include gas-filled internal pores. The markers may have a non-uniform surface contour to enhance the acoustic signature. The markers have a characteristic form which is recognizably artificial during medical imaging. The biopsy site marker may be accurately fixed to the biopsy site so as to resist migration from the biopsy cavity when a placement instrument is withdrawn, and when the marked tissue is subsequently moved or manipulated.
First Claim
Related Publications
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
|
|
|||
| 6,228,055 Devices for marking and defining particular locations in body tissue | 135 | 1997 | |
| 6,261,302 Applier for implantable surgical marker | 77 | 1998 | |
| 6,220,248 Method for implanting a biopsy marker | 104 | 1998 | |
| 6,356,782 Subcutaneous cavity marking device and method | 123 | 1999 | |
| 6,270,464 Biopsy localization method and device | 60 | 1999 | |
| 6,371,904 Subcutaneous cavity marking device and method | 87 | 1999 | |
| 2002/0035,324 Subcutaneous cavity marking device and method | 32 | 2001 | |
| 2006/0036,159 Biopsy cavity marking device | 16 | 2005 | |
|
|
|||
| 6,161,034 Methods and chemical preparations for time-limited marking of biopsy sites | 142 | 1999 | |
| 2003/0233,101 Plugged tip delivery tube for marker placement | 44 | 2002 | |
| 2004/0236,211 Marker or filler forming fluid | 14 | 2003 | |
| 2004/0101,479 Biopsy site marker and process and apparatus for applying it | 15 | 2003 | |
| 2004/0236,213 Marker delivery device with releasable plug | 25 | 2004 | |
| 2005/0065,453 Biopsy device with selectable tissue receiving aperture orientation and site illumination | 32 | 2004 | |
| 2005/0119,562 Fibrous marker formed of synthetic polymer strands | 25 | 2004 | |
| 2005/0143,656 Cavity-filling biopsy site markers | 13 | 2004 | |
|
|
|||
| 5,629,008 Method and device for long-term delivery of drugs | 85 | 1994 | |
| 6,251,418 Systems and methods for local delivery of an agent | 80 | 1997 | |
| 6,766,186 Post biospy tissue marker and method of use | 57 | 1999 | |
| 6,450,937 Needle for implanting brachytherapy seeds | 123 | 1999 | |
|
|
|||
| 5,281,408 Low density microspheres and their use as contrast agents for computed tomography | 135 | 1993 | |
| 5,334,381 Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same | 168 | 1993 | |
|
|
|||
| 5,282,781 Source wire for localized radiation treatment of tumors | 146 | 1990 | |
|
|
|||
| 5,508,021 Non-fluorinated polymeric shells for medical imaging | 85 | 1994 | |
|
|
|||
| 4,647,480 Use of additive in aqueous cure of autodeposited coatings | 56 | 1985 | |
|
|
|||
| 2005/0045,192 Biopsy localization method and device | 14 | 2004 | |
|
|
|||
| 6,234,177 Apparatus and method for deploying an expandable biopsy marker | 65 | 1999 | |
|
|
|||
| 6,350,244 Bioabsorable markers for use in biopsy procedures | 42 | 2000 | |
|
|
|||
| 5,902,310 Apparatus and method for marking tissue | 191 | 1997 | |
|
|
|||
| 5,688,490 Mucoadhesive compositions for increasing the ultrasonic image contrast of the digestive tract | 108 | 1996 | |
|
|
|||
| 5,289,831 Surface-treated stent, catheter, cannula, and the like | 198 | 1992 | |
|
|
|||
| 4,545,367 Detachable balloon catheter and method of use | 172 | 1983 | |
|
|
|||
| 4,331,654 Magnetically-localizable, biodegradable lipid microspheres | 220 | 1980 | |
|
|
|||
| 5,236,410 Tumor treatment method | 150 | 1991 | |
|
|
|||
| 5,676,925 Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons | 55 | 1995 | |
|
|
|||
| 5,636,255 Method and apparatus for CT image registration | 69 | 1996 | |
|
|
|||
| 5,549,560 Apparatus and method for injecting a pharmaceutical preparation in solid form | 48 | 1995 | |
|
|
|||
| 6,575,888 Bioabsorbable brachytherapy device | 55 | 2001 | |
|
|
|||
| 5,368,030 Non-invasive multi-modality radiographic surface markers | 181 | 1992 | |
|
|
|||
| 5,394,875 Automatic ultrasonic localization of targets implanted in a portion of the anatomy | 173 | 1993 | |
|
|
|||
| 4,863,470 Identification marker for a breast prosthesis | 113 | 1987 | |
|
|
|||
| 5,643,246 Electromagnetically triggered, responsive gel based drug delivery device | 60 | 1995 | |
|
|
|||
| 6,746,661 Brachytherapy seed | 42 | 2001 | |
|
|
|||
| 4,813,062 Radio-opaque marker and method | 55 | 1986 | |
|
|
|||
| 5,422,730 Automated optical detection of tissue perfusion by microspheres | 47 | 1994 | |
|
|
|||
| 5,853,366 Marker element for interstitial treatment and localizing device and method using same | 138 | 1996 | |
|
|
|||
| 5,646,146 Heterocyclic compounds and their preparation and use | 40 | 1995 | |
|
|
|||
| 5,433,204 Method of assessing placentation | 133 | 1993 | |
|
|
|||
| 6,071,310 Spinal implant | 40 | 1998 | |
|
|
|||
| 6,056,700 Biopsy marker assembly and method of use | 99 | 1998 | |
|
|
|||
| 2005/0268,922 Injectable snoring implant | 14 | 2005 | |
|
|
|||
| 4,276,885 Ultrasonic image enhancement | 269 | 1979 | |
|
|
|||
| 5,782,775 Apparatus and method for localizing and removing tissue | 83 | 1996 | |
|
|
|||
| 5,395,319 Needle for inserting an object into the body | 53 | 1994 | |
|
|
|||
| 2006/0079,805 Site marker visable under multiple modalities | 19 | 2004 | |
|
|
|||
| 5,281,197 Endoscopic hemostatic agent delivery system | 64 | 1992 | |
|
|
|||
| 5,494,030 Apparatus and methodology for determining oxygen in biological systems | 69 | 1993 | |
|
|
|||
| 6,656,192 Site marker device | 24 | 2001 | |
|
|
|||
| 5,081,997 Echogenic devices, material and method | 95 | 1989 | |
|
|
|||
| 2004/0236,212 Fibrous marker and intracorporeal delivery thereof | 22 | 2003 | |
|
|
|||
| 4,847,049 Method of forming chelated collagen having bactericidal properties | 100 | 1987 | |
|
|
|||
| 4,197,846 Method for structure for situating in a living body agents for treating the body | 88 | 1975 | |
| 4,294,241 Collagen skin dressing | 59 | 1979 | |
| 4,693,237 Radiopaque coded ring markers for use in identifying surgical grafts | 71 | 1986 | |
| 4,909,250 Implant system for animal identification | 109 | 1988 | |
| 5,147,307 Anatomical marker device and method | 67 | 1991 | |
| 7,172,549 Radioactive therapeutic seed having selective marker configuration | 9 | 2004 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 3.5 Year Payment | $1600.00 | $800.00 | $400.00 | Jan 21, 2013 |
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jan 21, 2017 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jan 21, 2021 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 3.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 7.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |