Enzymatic activities in chemokine-mediated inflammation
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United States of America Patent
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Aug 11, 2009
Grant Date -
Mar 23, 2006
app pub date -
Aug 4, 2005
filing date -
Aug 4, 2004
priority date (Note) -
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Abstract
Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1 and/or FPRL1 activity either by modulating the production of the truncated chemokines or the ability of the truncated chemokines to activate CCR1 and/or FPRL1 are also disclosed. Methods using the truncated chemokines to inhibit or activate CCR1 and/or FPRL1 mediated biological activities are also disclosed.
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