Pulsatile release compositions and methods for enhanced intestinal oligonucleotide drug absorption
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United States of America Patent
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Aug 18, 2009
Grant Date -
Sep 8, 2005
app pub date -
Dec 1, 2004
filing date -
Aug 22, 2001
priority date (Note) -
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Abstract
Delayed release oral pharmaceutical formulations and methods for enhanced intestinal drug absorption. The formulation comprises a first population of carrier particles comprising a drug and a penetration enhancer which are released at a first location in the intestine, and a second population of carrier particles comprising a penetration enhancer and a delayed release coating or matrix. This penetration enhancer is released at a second location in the intestine downstream from the first location and enhances absorption of the drug when it reaches the second location.
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